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[红霉素、克林霉素和林可霉素在唾液中的排泄情况]

[Excretion of erythromycin, clindamycin and lincomycin into the saliva].

作者信息

Kelentey B A, Kelentey B J

机构信息

Debreceni Orvostudományi Egyetem, Stomatologiai Klinika, Debrecen.

出版信息

Fogorv Sz. 1995 Jul;88(7):219-24.

PMID:8522016
Abstract

In rabbit experiments (n = 10) the salivary and serum levels of several antibiotics were studied after per os (clindamycin, erythromycin and lincomycin) and iv. (erythromycin) administration. Erythromycin was excreted into the saliva in a considerable degree (in 60-75% of the serum level) and displayed therapeutical levels for 5-6 hrs, whereas clindamycin and lincomycin reached in the saliva only 25-30% of the serum level and therapeutic levels were maintained only for 3 hours.

摘要

在兔子实验(n = 10)中,研究了经口(克林霉素、红霉素和林可霉素)和静脉注射(红霉素)给药后几种抗生素的唾液和血清水平。红霉素在相当程度上分泌到唾液中(为血清水平的60 - 75%),并在5 - 6小时内保持治疗水平,而克林霉素和林可霉素在唾液中的水平仅为血清水平的25 - 30%,且仅在3小时内维持治疗水平。

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