Leturque A, Loizeau M, Vaulont S, Salminen M, Girard J
Centre de Recherche sur l'Endocrinologie Moléculaire et le Développement, Meudon-Bellevue, France.
Diabetes. 1996 Jan;45(1):23-7. doi: 10.2337/diab.45.1.23.
To investigate the role of glucose transporter expression in whole-body glucose homeostasis, we have created transgenic mice that have a 2.0- to 3.5-fold increase in GLUT4 glucose transporter level in skeletal muscle and heart. This increase is sufficient to significantly improve insulin action and to reduce basal blood glucose levels in transgenic streptozotocin-induced diabetic mice. These results provide the first evidence of a direct causality between skeletal muscle GLUT4 transporter level and overall insulin responsiveness.
为了研究葡萄糖转运蛋白表达在全身葡萄糖稳态中的作用，我们构建了转基因小鼠，其骨骼肌和心脏中GLUT4葡萄糖转运蛋白水平增加了2.0至3.5倍。这种增加足以显著改善转基因链脲佐菌素诱导的糖尿病小鼠的胰岛素作用，并降低其基础血糖水平。这些结果首次证明了骨骼肌GLUT4转运蛋白水平与整体胰岛素反应性之间存在直接因果关系。
