氯离子通道2基因（Clc2）定位于小鼠的16号染色体，扩展了与人类3号染色体q臂的保守同线性区域。

Chloride channel 2 gene (Clc2) maps to chromosome 16 of the mouse, extending a region of conserved synteny with human chromosome 3q.

作者信息

Lengeling A, Gronemeier M, Ronsiek M, Thiemann A, Jentsch T J, Jockusch H

机构信息

Developmental Biology Unit, University of Bielefeld, Federal Republic of Germany.

出版信息

Genet Res. 1995 Oct;66(2):175-8. doi: 10.1017/s0016672300034522.

DOI:10.1017/s0016672300034522

PMID:8522159

Abstract

The Clc2 gene of the mouse codes for the ubiquitously expressed chloride channel ClC-2, a member of a family of at least seven voltage gated chloride channels, some of which are implicated in hereditary diseases. Using a mouse interspecies back-cross panel, we have mapped Clc2 to Chr 16, proximal to the somatostatin gene Smst, extending a region of documented conserved synteny to human Chr 3q.

摘要

小鼠的Clc2基因编码普遍表达的氯离子通道ClC-2，它是一个至少由七个电压门控氯离子通道组成的家族的成员，其中一些与遗传性疾病有关。利用小鼠种间回交群体，我们已将Clc2定位到16号染色体上，靠近生长抑素基因Smst，将已记录的保守同线性区域扩展到人类3号染色体长臂。