Postel-Vinay M C, Saab C, Gourmelen M
INSERM Unité 344, Faculté de Médecine Necker, Paris, France.
Horm Res. 1995;44(4):177-81. doi: 10.1159/000184621.
To study the effects of nutrition on growth hormone (GH) receptor status, the plasma GH-binding protein was evaluated under conditions of poor nutrition, anorexia nervosa, celiac disease, and obesity. Nine patients, aged 12-30 years, presented anorexia nervosa and had a mean weight loss of -19% of their initial weight at the time of the study. Ten patients with celiac disease, aged 3-14 years, had a mean height at -4.2 SD, and normal body weight for height. Fourteen severely obese children, aged 3-10 years, had a mean body mass index (BMI) of 25.7 +/- 0.9. GH-binding protein was low in patients with anorexia nervosa (16.8 +/- 1.9% of radioactivity) and in patients with celiac disease (16.1 +/- 2.2%) whereas it was very high in obese children (57.2 +/- 3.3%). A strong correlation was found between GH-binding protein and BMI. GH-binding protein was also correlated with insulin-like growth factor-1 plasma levels. Nutrition is an important regulator of the GH receptor/binding protein. The growth failure presented by undernourished children is associated with partial GH resistance and low GH receptor level. On the contrary, children with obesity and normal growth have a high GH receptor level.
为研究营养对生长激素（GH）受体状态的影响，对营养不良、神经性厌食症、乳糜泻和肥胖症患者的血浆GH结合蛋白进行了评估。9名年龄在12至30岁之间的神经性厌食症患者，在研究时平均体重减轻了初始体重的19%。10名年龄在3至14岁之间的乳糜泻患者，平均身高低于标准差4.2，身高对应的体重正常。14名年龄在3至10岁之间的重度肥胖儿童，平均体重指数（BMI）为25.7±0.9。神经性厌食症患者（放射性的16.8±1.9%）和乳糜泻患者（16.1±2.2%）的GH结合蛋白水平较低，而肥胖儿童的GH结合蛋白水平非常高（57.2±3.3%）。发现GH结合蛋白与BMI之间存在强相关性。GH结合蛋白也与胰岛素样生长因子-1血浆水平相关。营养是GH受体/结合蛋白的重要调节因子。营养不良儿童出现的生长发育迟缓与部分GH抵抗和低GH受体水平有关。相反，肥胖且生长正常的儿童GH受体水平较高。
