Aboud E, De Swiet M, Gordon H
Northwick Park Hospital, Harrow, Middlesex.
Ir J Med Sci. 1995 Oct-Dec;164(4):279-80. doi: 10.1007/BF02967204.
We report a case of primary aldosteronism in pregnancy that was treated surgically by removal of the adenoma in the 2nd trimester. Only a few cases have been reported in the English literature due to the rarity of the condition. Primary aldosteronism follows a variable course in pregnancy. In the majority of cases the hypertension and hypokalaemia are made worse, necessitating antihypertensive medication to control the blood pressure. Some of the drugs required for treatment are known to affect the fetus. In a minority of cases the hypertension improves with pregnancy. This is thought to be due to the high levels of progesterone which is an aldosterone antagonist. Primary aldosteronism invariably gets worse in the post partum period, irrespective of the antenatal course of the disease. Surgery seems to be the treatment of choice for this condition, provided the adenoma is localised. It has the advantage of offering an immediate solution, avoids fetal complications of medical treatment and possible deterioration in the post partum period.
我们报告了一例妊娠期原发性醛固酮增多症病例，该患者在孕中期通过手术切除腺瘤进行治疗。由于该病罕见，英文文献中仅报道了少数病例。原发性醛固酮增多症在妊娠期的病程多变。在大多数情况下，高血压和低钾血症会加重，需要使用抗高血压药物来控制血压。一些治疗所需的药物已知会影响胎儿。在少数情况下，高血压会随着妊娠而改善。这被认为是由于高水平的孕酮，它是一种醛固酮拮抗剂。无论产前疾病进程如何，原发性醛固酮增多症在产后总是会恶化。手术似乎是这种情况的首选治疗方法，前提是腺瘤已定位。它具有提供即时解决方案的优点，避免了药物治疗的胎儿并发症以及产后可能的病情恶化。
