Abu-Eshy S A, Khan A R, Khan G M, al-Humaidi M A, al-Shehri M Y, Malatani T S
Department of Surgery, Asir Central Hospital, King Saud University, Abha Branch, Saudi Arabia.
J R Coll Surg Edinb. 1995 Oct;40(5):310-2.
This is a retrospective study of 361 thyroid specimens during a 6 1/2-year period with the objective of investigating the prevalence and pattern of thyroid malignancy associated with multinodular goitre (MNG) and solitary nodule (SN). Fourteen of 172 MNG (8%) and 16 of 105 SN (15.2%) were associated with malignancy, a statistically insignificant difference (P = 0.06). Unlike in males, malignancy was significantly commoner in females with SN than those with MNG (P = 0.03) and generally occurred at a significantly older age (P < 0.05). On analysing thyroid carcinoma and lymphoma separately, patients with SN had a higher incidence of carcinoma compared with those with MNG (P = 0.01). It is concluded that surgical intervention may be the appropriate method of treating male patients presenting with MNG. However, in females, conservative management of MNG should be adopted unless surgery is indicated depending on clinical judgement and, if feasible, the result of fine needle aspiration biopsy.
这是一项对361份甲状腺标本进行的回顾性研究，研究为期6年半，目的是调查与多结节性甲状腺肿（MNG）和孤立性结节（SN）相关的甲状腺恶性肿瘤的患病率和模式。172例MNG中有14例（8%）以及105例SN中有16例（15.2%）与恶性肿瘤相关，差异无统计学意义（P = 0.06）。与男性不同，女性中SN伴发恶性肿瘤的情况比MNG更为常见（P = 0.03），且通常发生在显著更大的年龄（P < 0.05）。分别分析甲状腺癌和淋巴瘤时，SN患者的癌发病率高于MNG患者（P = 0.01）。结论是，手术干预可能是治疗出现MNG的男性患者的合适方法。然而，对于女性，除非根据临床判断表明需要手术，并且如果可行的话，根据细针穿刺活检的结果，否则应采取MNG的保守治疗方法。
