Koibuchi Y, Lino Y, Joshita T, Yokoe T, Shinkai H, Kawashima K, Kobayashi J, Tanaka S, Oyama T, Hikino T
Second Department of Surgery, Gunma University School of Medicine, Maebashi.
Jpn J Clin Oncol. 1995 Dec;25(6):273-7.
A 66-year-old woman developed a malignant rhabdoid tumor of the breast, with a tumor doubling time of 10 days. One month after radical mastectomy, there was local recurrence, followed by multiple pulmonary metastases, and the patient died of respiratory failure 5 months after surgery. The gray-white-colored tumor measured 13 x 12 x 10 cm, and its border was well defined. The tumor was composed of diffusely growing round or polygonal cells with vesicular nuclei, prominent nucleoli, and ample cytoplasm containing eosinophilic inclusions. Lymph node involvement was widespread. Both vimentin and keratin were clearly demonstrated by immunohistochemical staining. Ultrastructural studies revealed that the MRT cells contained cytoplasmic whorls of intermediate filaments.
一名66岁女性患乳腺恶性横纹肌样瘤，肿瘤倍增时间为10天。根治性乳房切除术后1个月出现局部复发，随后发生多发性肺转移，患者术后5个月死于呼吸衰竭。灰白色肿瘤大小为13×12×10 cm，边界清晰。肿瘤由弥漫性生长的圆形或多边形细胞组成，细胞核呈泡状，核仁突出，细胞质丰富，含有嗜酸性包涵体。淋巴结受累广泛。免疫组织化学染色清楚地显示波形蛋白和角蛋白均呈阳性。超微结构研究显示，横纹肌样瘤细胞含有中间丝的细胞质涡旋。
