Matsumoto K, Sugihara H, Ito K, Terada K, Taniguchi Y, Ohtsuki K, Nakata T, Ushijima Y, Maeda T, Nakagawa M
Second Department of Medicine, Kyoto Prefectural University of Medicine.
Kaku Igaku. 1995 Sep;32(9):1023-8.
A 55-year-old man with pheochromocytoma was examined by 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy before and after resection of the tumor. MIBG images showed decreased uptake in infero-posterior wall before operation. The heart to upper mediastinum uptake ratio was low at the delayed anterior planar image, and mean MIBG clearance from the left ventricle was increased. These abnormal scintigraphic findings improved after resection of the tumor. We thought that these abnormal MIBG findings were not due to abnormal cardiac sympathetic nerve function, because ECG, chest X-ray, UCG and 201Tl myocardial scintigram did not reveal any abnormality. It may be presumed that these abnormal MIBG findings were caused by high plasma catecholamines concentration. The mechanism of abnormal MIBG findings of the heart remains uncertain in various heart diseases. MIBG findings in this case with pheochromocytoma before and after resection may contribute to interpretation of the kinetics of MIBG in heart.
一名55岁的嗜铬细胞瘤患者在肿瘤切除前后接受了123I-间碘苄胍（MIBG）心肌闪烁显像检查。MIBG图像显示术前下后壁摄取减少。在延迟前位平面图像上，心脏与上纵隔的摄取比值较低，左心室的平均MIBG清除率增加。肿瘤切除后，这些异常的闪烁显像结果得到改善。我们认为这些异常的MIBG表现并非由于心脏交感神经功能异常，因为心电图、胸部X线、超声心动图和201Tl心肌闪烁显像均未发现任何异常。可以推测，这些异常的MIBG表现是由高血浆儿茶酚胺浓度引起的。在各种心脏病中，心脏MIBG异常表现的机制仍不确定。该嗜铬细胞瘤病例切除前后的MIBG表现可能有助于解释心脏中MIBG的动力学。
