Morishita K, Kambe M
Department of Clinical Laboratory Medicine, Hiroshima University School of Medicine, Hiroshima City, Japan.
Med Biol Eng Comput. 1995 Sep;33(5):699-703. doi: 10.1007/BF02510789.
To non-invasively determine abdominal aortic properties, a five-element lumped circuit model was adopted. The model consists of resistance due to blood viscosity (R1), inertia of blood flow, compliances of the vessel (C1, C2), resistance of the peripheral arteries (R2) and the impedance of the of the femoral arteries (termination). Patterns of the central velocity of the upper abdominal aorta and the femoral artery are measured by pulsed Doppler echocardiography, and contours of flow volume rates are calculated. The pressure pattern of the lower limb is recorded by a pulse wave transducer and corrected according to sphygmomanometer values. Contours are transformed into respective Fourier transform components. The current transfer function is described theoretically and calculated from the acquired Fourier components. Values of every element are evaluated by the nonlinear least squares method. In 94 subjects (17-92 years), the values of each element are estimated. R2 values are greater in the elderly group than in the young group and r1 (R1/cm) increased with age. This model demonstrates that vessel compliance (C1 + C2 (C1 + C2/cm)) decreases with age, and it is suggested that this may be a useful marker of arteriosclerosis.
为了无创地测定腹主动脉特性,采用了一个五元集总电路模型。该模型由血液粘度引起的阻力(R1)、血流惯性、血管顺应性(C1、C2)、外周动脉阻力(R2)以及股动脉阻抗(终端)组成。通过脉冲多普勒超声心动图测量上腹部主动脉和股动脉的中心速度模式,并计算流量率轮廓。下肢压力模式由脉搏波传感器记录,并根据血压计值进行校正。轮廓被转换为各自的傅里叶变换分量。从理论上描述电流传递函数,并根据采集到的傅里叶分量进行计算。每个元件的值通过非线性最小二乘法进行评估。在94名受试者(17 - 92岁)中,估计了每个元件的值。老年组的R2值高于年轻组,且r1(R1/cm)随年龄增加。该模型表明血管顺应性(C1 + C2(C1 + C2/cm))随年龄降低,并且提示这可能是动脉硬化的一个有用标志物。