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通过血管植入实现复合软骨皮肤移植物的存活:兔耳模型研究

Survival of composite chondrocutaneous grafts by vessel implantation: a study in the rabbit ear model.

作者信息

Arden R L, Smith D M, Salley S O, Sakr W A, Doerr T D

机构信息

Department of Otolaryngology--Head and Neck Surgery, Harper-Grace Hospitals, Wayne State University School of Medicine, Detroit, MI 48201, USA.

出版信息

Laryngoscope. 1995 Dec;105(12 Pt 1):1326-33. doi: 10.1288/00005537-199512000-00012.

Abstract

Composite chondrocutaneous graft reconstruction or reattachment has limited applicability, is traditionally restricted to small segmental losses, and is dependent on the status of the recipient bed and graft periphery for successful revascularization. Surgical enhancement of composite graft survival was experimentally investigated in the rabbit ear model through transposition and appositional placement of an adjacent vascular pedicle. Fluorescein-derived surface-survival determinations, microangiographic vessel-counting methods, and histologic analysis were used to study the effects of vascular augmentation, pedicle design variations, and angiogenic substance in sixty 8-cm2, full-thickness auricular grafts. A statistically significant survival advantage was demonstrated for the implanted grafts, secondary to perivascular angiogenesis from the implanted pedicle.

摘要

复合软骨皮肤移植重建或重新附着的适用性有限,传统上仅限于小面积节段性缺损,并且其成功再血管化取决于受区床和移植物周边的状况。通过将相邻血管蒂移位并并置放置,在兔耳模型中对复合移植物存活的手术增强进行了实验研究。使用荧光素衍生的表面存活测定、微血管造影血管计数方法和组织学分析,研究了血管增强、蒂设计变化和血管生成物质对60块8平方厘米全层耳廓移植物的影响。植入的移植物显示出统计学上显著的存活优势,这归因于植入蒂周围血管生成。

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