de Lemos E R, Machado R D, Coura J R
Departamento de Medicina Tropical, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.
Mem Inst Oswaldo Cruz. 1994 Oct-Dec;89(4):497-501. doi: 10.1590/s0074-02761994000400001.
Only one species of spotted fever-group rickettsiae that is pathogenic for humans has been isolated in Brazil, where few physicians are familiar with this disease. In order to obtain information on tick-borne rickettsiosis, a study was performed in the County of Santa Cruz do Escalvado, State of Minas Gerais, Brazil, where a fatal clinical case confirmed by specific immunofluorescence had been reported. Serum samples obtained from 679 humans and 96 dogs were tested by indirect immunofluorescence for detectable antibodies to spotted fever-group rickettsiae, the criterion for a positive result being a titer > or = 1:64. Seropositivity was detected in 7.14% of the humans sera examined and 13.68% of the dogs. We discuss the significance of these findings and formulate some questions, emphasizing the need for further investigation.
在巴西，仅分离出了一种对人类致病的斑点热群立克次体，而当地很少有医生熟悉这种疾病。为了获取有关蜱传立克次体病的信息，在巴西米纳斯吉拉斯州圣克鲁斯 - 多埃斯卡瓦多县开展了一项研究，该县曾报告过一例经特异性免疫荧光确诊的致命临床病例。对从679名人类和96只狗身上采集的血清样本进行间接免疫荧光检测，以检测针对斑点热群立克次体的可检测抗体，阳性结果的标准为滴度≥1:64。在所检测的人类血清中，7.14%呈血清阳性，在狗血清中这一比例为13.68%。我们讨论了这些发现的意义并提出了一些问题，强调了进一步调查的必要性。
