• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.

作者信息

Alessi D R, Cohen P, Ashworth A, Cowley S, Leevers S J, Marshall C J

机构信息

Department of Biochemistry, University of Dundee, Scotland.

出版信息

Methods Enzymol. 1995;255:279-90. doi: 10.1016/s0076-6879(95)55031-3.

DOI:10.1016/s0076-6879(95)55031-3
PMID:8524112
Abstract
摘要

相似文献

1
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.丝裂原活化蛋白激酶、丝裂原活化蛋白激酶激酶和Raf的检测与表达
Methods Enzymol. 1995;255:279-90. doi: 10.1016/s0076-6879(95)55031-3.
2
Assay of MEK kinases.MEK激酶的测定
Methods Enzymol. 1995;255:290-301. doi: 10.1016/s0076-6879(95)55032-1.
3
Site-related specificities of the control by androgenic status of adipogenesis and mitogen-activated protein kinase cascade/c-fos signaling pathways in rat preadipocytes.大鼠前脂肪细胞中脂肪生成及丝裂原活化蛋白激酶级联/c-fos信号通路的雄激素状态调控的位点相关特异性
Endocrinology. 1997 Aug;138(8):3181-6. doi: 10.1210/endo.138.8.5290.
4
Cot protooncoprotein activates the dual specificity kinases MEK-1 and SEK-1 and induces differentiation of PC12 cells.Cot原癌蛋白激活双特异性激酶MEK-1和SEK-1并诱导PC12细胞分化。
Oncogene. 1999 Feb 18;18(7):1391-400. doi: 10.1038/sj.onc.1202431.
5
The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation.Ras激酶抑制因子（KSR）通过使Elk-1磷酸化与丝裂原活化蛋白激酶（MAP激酶）激活解偶联来调节生长因子和Ras信号传导。
EMBO J. 1998 Mar 16;17(6):1717-27. doi: 10.1093/emboj/17.6.1717.
6
Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis.丝裂原活化蛋白（MAP）激酶对MAP激酶激酶的磷酸化：通过质谱法和定点诱变确定磷酸化位点
J Biochem. 1994 Aug;116(2):304-14. doi: 10.1093/oxfordjournals.jbchem.a124524.
7
Measuring activation of kinases in mitogen-activated protein kinase regulatory network.测量丝裂原活化蛋白激酶调控网络中激酶的活性。
Methods Enzymol. 1994;238:258-70. doi: 10.1016/0076-6879(94)38024-4.
8
Immune complex kinase assays for mitogen-activated protein kinase and MEK.用于丝裂原活化蛋白激酶和丝裂原活化蛋白激酶激酶的免疫复合物激酶分析
Methods Enzymol. 1995;255:245-56. doi: 10.1016/s0076-6879(95)55027-5.
9
Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events.鼠巨噬细胞中Raf-1和丝裂原活化蛋白激酶的激活部分模拟了脂多糖诱导的信号事件。
J Exp Med. 1995 Jul 1;182(1):147-54. doi: 10.1084/jem.182.1.147.
10
Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP.PC12细胞中丝裂原活化蛋白激酶（MAP激酶）级联反应的调控：B-Raf激活MEK-1（丝裂原活化蛋白激酶或细胞外信号调节激酶）并受环磷酸腺苷（cAMP）抑制。
FEBS Lett. 1995 Jan 9;357(3):290-6. doi: 10.1016/0014-5793(94)01376-c.

引用本文的文献

1
Kinase drug discovery--what's next in the field?激酶药物研发——该领域的下一步是什么？
ACS Chem Biol. 2013 Jan 18;8(1):96-104. doi: 10.1021/cb300610s. Epub 2012 Dec 31.
2
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.MO25 是 SPAK/OSR1 和 MST3/MST4/YSK1 蛋白激酶的主要调节因子。
EMBO J. 2011 May 4;30(9):1730-41. doi: 10.1038/emboj.2011.78. Epub 2011 Mar 18.
3
Hypoxia-induced activation of epidermal growth factor receptor (EGFR) kinase in the cerebral cortex of newborn piglets: the role of nitric oxide.
缺氧诱导新生仔猪大脑皮层表皮生长因子受体（EGFR）激酶的激活：一氧化氮的作用。
Neurochem Res. 2010 Sep;35(9):1471-7. doi: 10.1007/s11064-010-0208-1. Epub 2010 Jun 8.
4
ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.三磷酸腺苷（ATP）和MO25α调节STRADα伪激酶的构象状态以及抑癌基因LKB1的激活。
PLoS Biol. 2009 Jun 9;7(6):e1000126. doi: 10.1371/journal.pbio.1000126.
5
NO-mediated activation of Src kinase during hypoxia in the cerebral cortex of newborn piglets.新生仔猪大脑皮层缺氧时一氧化氮介导的Src激酶激活。
Neurosci Lett. 2009 Aug 21;460(1):61-5. doi: 10.1016/j.neulet.2009.05.041. Epub 2009 May 20.
6
Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase.白细胞介素-1（IL-1）诱导IL-1受体相关激酶1的赖氨酸63连接的多聚泛素化，以促进NEMO结合和IkappaBalpha激酶的激活。
Mol Cell Biol. 2008 Mar;28(5):1783-91. doi: 10.1128/MCB.02380-06. Epub 2008 Jan 7.
7
The selectivity of protein kinase inhibitors: a further update.蛋白激酶抑制剂的选择性：进一步更新
Biochem J. 2007 Dec 15;408(3):297-315. doi: 10.1042/BJ20070797.
8
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.BI-D1870在体外和体内均是p90核糖体S6激酶（RSK）亚型的特异性抑制剂。
Biochem J. 2007 Jan 1;401(1):29-38. doi: 10.1042/BJ20061088.
9
C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival.秀丽隐杆线虫的GLA-3是生殖细胞存活所需的丝裂原活化蛋白激酶MPK-1信号通路的一个新组分。
Genes Dev. 2006 Aug 15;20(16):2279-92. doi: 10.1101/gad.384506.
10
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.SPAK/OSR1激酶与其上游激活因子WNK1和下游底物NKCC1之间的功能相互作用。
Biochem J. 2006 Jul 1;397(1):223-31. doi: 10.1042/BJ20060220.