van Melick E J, Touw D J, Haak H L
Psychiatrisch Centrum Rosenburg, 's-Gravenhage.
Ned Tijdschr Geneeskd. 1995 Nov 25;139(47):2437-40.
In four patients, a woman aged 85 and three men aged 33, 42 and 70 years, clozapine-induced agranulocytosis was diagnosed. In three patients the white cell counts were not performed as they should have been. Two patients were treated for their agranulocytosis with granulocyte colony-stimulating factor (G-CSF; filgrastim). Two patients were not treated. The literature concerning clozapine-induced agranulocytosis and its treatment with growth factors consists of only a few case reports. Therefore a definite conclusion about the efficacy of the treatment for this particular indication is not yet possible.
在4例患者中，确诊为氯氮平所致粒细胞缺乏症，其中1名85岁女性，3名男性，年龄分别为33岁、42岁和70岁。3例患者未按要求进行白细胞计数。2例粒细胞缺乏症患者接受了粒细胞集落刺激因子（G-CSF；非格司亭）治疗。2例患者未接受治疗。关于氯氮平所致粒细胞缺乏症及其生长因子治疗的文献仅包含少数病例报告。因此，对于该特定适应症治疗的疗效尚无法得出明确结论。
