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[甲状腺激素在大鼠肝脏和脑细胞个体发育过程中的膜受体结合]

[The membrane receptor binding of thyroid hormones in rat liver and brain cells in ontogeny].

作者信息

Guliamova F Ia, Iakovleva N N, Ivanov V I, Saatov T S

出版信息

Ontogenez. 1995 Sep-Oct;26(5):370-5.

PMID:8524545
Abstract

We studied changes of phospholipid and fatty acid composition of highly purified plasma membranes of liver and brain cells of rats over time during ontogenesis. Membranes were isolated from the organs of 2-day-old embryos, 6-day-old newborn rats, and adult rats. We examined the binding of thyroxine, a thyroid hormone, by preparations of plasma membranes from liver and brain at these times and have determined any tissue specificity in the development of membrane-mediated thyroxine reception during ontogenesis.

摘要

我们研究了大鼠肝脏和脑细胞高度纯化的质膜在个体发育过程中磷脂和脂肪酸组成随时间的变化。质膜取自2日龄胚胎、6日龄新生大鼠和成年大鼠的器官。我们检测了这些时期肝脏和脑组织质膜制剂对甲状腺激素甲状腺素的结合情况,并确定了个体发育过程中膜介导的甲状腺素受体发育的任何组织特异性。

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