以FeS/H2S作为还原剂，对由二氧化碳进行氨基酸和RNA碱基的益生元合成的研究。
Investigation of the prebiotic synthesis of amino acids and RNA bases from CO2 using FeS/H2S as a reducing agent.
作者信息
Keefe A D, Miller S L, McDonald G, Bada J
机构信息
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093, USA.
出版信息
Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11904-6. doi: 10.1073/pnas.92.25.11904.
An autotrophic theory of the origin of metabolism and life has been proposed in which carbon dioxide is reduced by ferrous sulfide and hydrogen sulfide by means of a reversed citric acid cycle, leading to the production of amino acids. Similar processes have been proposed for purine synthesis. Ferrous sulfide is a strong reducing agent in the presence of hydrogen sulfide and can produce hydrogen as well as reduce alkenes, alkynes, and thiols to saturated hydrocarbons and reduce ketones to thiols. However, the reduction of carbon dioxide has not been demonstrated. We show here that no amino acids, purines, or pyrimidines are produced from carbon dioxide with the ferrous sulfide and hydrogen sulfide system. Furthermore, this system does not produce amino acids from carboxylic acids by reductive amination and carboxylation. Thus, the proposed autotrophic theory, using carbon dioxide, ferrous sulfide, and hydrogen sulfide, lacks the robustness needed to be a geological process and is, therefore, unlikely to have played a role in the origin of metabolism or the origin of life.
一种关于新陈代谢和生命起源的自养理论被提出，该理论认为，通过逆向柠檬酸循环，二氧化碳被硫化亚铁和硫化氢还原，从而产生氨基酸。嘌呤合成也被认为有类似过程。在硫化氢存在的情况下，硫化亚铁是一种强还原剂，它可以产生氢气，还能将烯烃、炔烃和硫醇还原为饱和烃，并将酮还原为硫醇。然而，二氧化碳的还原尚未得到证实。我们在此表明，在硫化亚铁和硫化氢体系中，二氧化碳不会产生氨基酸、嘌呤或嘧啶。此外，该体系也不会通过还原胺化和羧化作用从羧酸中产生氨基酸。因此，所提出的利用二氧化碳、硫化亚铁和硫化氢的自养理论，缺乏作为一种地质过程所需的稳健性，所以不太可能在新陈代谢起源或生命起源中发挥作用。
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