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Plasma concentrations of propranolol in patients with essential hypertension.

作者信息

Lehtonen A, Kanto J, Kleimola T

出版信息

Eur J Clin Pharmacol. 1977 Mar 11;11(3):155-7. doi: 10.1007/BF00606403.

DOI:10.1007/BF00606403
PMID:852494
Abstract

Sixteen patients with essentialy hypertension were treated with propranolol 160 to 640 mg daily for three months. Significant decreases both in recumbent and standing blood pressure were observed after three days treatment and subsequently. Reduction of blood pressure was more pronounced when the dose of propranolol was increased. However, neither the mean dose nor the plasma concentration of propranolol could be correlated with the mean decrease in blood pressure. There was great interindividual variation in the plasma concentrations of propranolol produced by the same daily dose. The initial stimulation of plasma renin activity and the therapeutic response to propranolol could not be correlated.

摘要

相似文献

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引用本文的文献

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Correlation between propranolol in plasma and urine, renin-aldosterone system and blood pressure in essential hypertension.原发性高血压患者血浆与尿液中普萘洛尔、肾素-醛固酮系统及血压之间的相关性
Eur J Clin Pharmacol. 1981;20(4):251-8. doi: 10.1007/BF00618774.
2
A dose ranging study of atenolol in hypertension: fall in blood pressure and plasma renin activity, beta-blockade and steady-state pharmacokinetics.阿替洛尔治疗高血压的剂量范围研究：血压和血浆肾素活性的降低、β受体阻滞及稳态药代动力学
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Relationship of propranolol pharmacokinetics to antihypertensive effect and beta-adrenergic blockade in the treatment of hypertension.

本文引用的文献

1
Treatment of hypertension with propranolol.用普萘洛尔治疗高血压。
Br Med J. 1969 Jan 4;1(5635):7-16. doi: 10.1136/bmj.1.5635.7.
2
Plasma propranolol levels in adults with observations in four children.成人血浆普萘洛尔水平及对四名儿童的观察结果
Clin Pharmacol Ther. 1970 Jan-Feb;11(1):112-20. doi: 10.1002/cpt1970111112.
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Propranolol in hypertension: a study of long-term therapy, 1964-1970.普萘洛尔治疗高血压：1964 - 1970年长期治疗研究
普萘洛尔药代动力学与高血压治疗中降压效果及β-肾上腺素能阻滞的关系。
Eur J Clin Pharmacol. 1980 Nov;18(5):391-4. doi: 10.1007/BF00636790.
4
Clinical relevance of pharmacokinetics.药代动力学的临床相关性。
Clin Pharmacokinet. 1980 Mar-Apr;5(2):105-36. doi: 10.2165/00003088-198005020-00001.
5
Effects of dilevalol, an R, R-isomer of labetalol, on blood pressure and renal function in patients with mild-to-moderate essential hypertension.拉贝洛尔的R，R-异构体二利洛尔对轻至中度原发性高血压患者血压及肾功能的影响。
Eur J Clin Pharmacol. 1988;35(1):9-15. doi: 10.1007/BF00555500.
6
Pharmacokinetic and pharmacodynamic comparison of two doses of long acting propranolol (80 and 160 mg) in healthy subjects.健康受试者中两种剂量长效普萘洛尔（80毫克和160毫克）的药代动力学和药效学比较。
Br J Clin Pharmacol. 1989 May;27(5):539-45. doi: 10.1111/j.1365-2125.1989.tb03415.x.
7
The description and prediction of antihypertensive drug response: an individualised approach.抗高血压药物反应的描述与预测：一种个体化方法。
Br J Clin Pharmacol. 1991 Jun;31(6):627-34. doi: 10.1111/j.1365-2125.1991.tb05584.x.
8
Antihypertensive effect of various doses of hydrochlorothiazide and its relation to the plasma level of the drug.不同剂量氢氯噻嗪的降压作用及其与药物血浆水平的关系。
Eur J Clin Pharmacol. 1978 May 31;13(3):195-201. doi: 10.1007/BF00609982.
Am Heart J. 1972 Jun;83(6):755-61. doi: 10.1016/0002-8703(72)90206-2.
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Antihypertensive action of propranolol. Specific antirenin responses in high and normal renin forms of essential, renal, renovascular and malignant hypertension.普萘洛尔的降压作用。原发性、肾性、肾血管性和恶性高血压的高肾素型和正常肾素型中的特异性抗肾素反应。
Am J Cardiol. 1973 Sep 20;32(4):511-22. doi: 10.1016/s0002-9149(73)80043-8.
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Individualization of propranolol therapy.
Med Clin North Am. 1974 Sep;58(5):1063-9. doi: 10.1016/s0025-7125(16)32102-2.
6
Propranolol therapy in essential hypertension. Observations on predictability of therapeutic response.普萘洛尔治疗原发性高血压。关于治疗反应可预测性的观察。
Int J Clin Pharmacol. 1974 Sep;10(2):79-89.
7
Propranolol given twice daily in hypertension.普萘洛尔用于高血压治疗时，每日给药两次。
Acta Med Scand. 1973 Dec;194(6):513-5. doi: 10.1111/j.0954-6820.1973.tb19483.x.
8
Beta-blockers and plasma renin activity in hypertension.β受体阻滞剂与高血压患者的血浆肾素活性
Br Med J. 1974 Jan 12;1(5897):60-2. doi: 10.1136/bmj.1.5897.60.
9
Stimulated renin: a screening test for hypertension.刺激肾素：一种高血压筛查试验。
Ann Intern Med. 1975 Jan;82(1):27-34. doi: 10.7326/0003-4819-82-1-27.
10
Studies of the absorption and removal of propranolol in hypertensive patients during therapy.高血压患者治疗期间普萘洛尔吸收与清除情况的研究。
Circulation. 1975 Aug;52(2):313-8. doi: 10.1161/01.cir.52.2.313.