Zawilińska B, Kruszewska M, Stopyrowa J, Zgórniak-Nowosielska I
Zakładu Wirusologii, Instytutu Mikrobiologii, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Przegl Lek. 1995;52(7):354-7.
Sixty infants in whom clinical symptoms suspected of cytomegalovirus (CMV) infection were studied. CMV infection was found in 50% of the subjects. The diagnosis was based on studies of specific antibodies and isolation of the virus from urine and/or throat swabs. In most of the children the examinations were repeated several times, and clinical observations continued for 1 to 42 months (avg. 18 months). IgM-class antibodies were detected in 26 children and in 18 the virus was isolated. In 3 infants, isolation of CMV virus was the only evidence of active infection. Persisting viruria (avg. 11 months) and long-term presence of Ig G antibodies, even to 44th month of life were also observed. Congenital infection was diagnosed in 4 infants; the remaining ones acquired the infection during the perinatal period or later. In 7 cases transfused blood cannot be excluded as the source of infection. The clinical symptoms manifested in infected and non-infected children were similar. There was a statistically significant increase in the occurrence of hepatomegaly, splenomegaly, hyperbiliru-binemia and diarrhoea in infected children. Congenital abnormalities were found in 10 infected children, including 4 cases of congenital cytomegaly.
对60名有临床症状疑似巨细胞病毒（CMV）感染的婴儿进行了研究。在50%的受试者中发现了CMV感染。诊断基于特异性抗体研究以及从尿液和/或咽拭子中分离病毒。大多数儿童的检查重复了几次，临床观察持续了1至42个月（平均18个月）。在26名儿童中检测到IgM类抗体，18名儿童分离出病毒。在3名婴儿中，CMV病毒分离是活动性感染的唯一证据。还观察到持续性病毒尿（平均11个月）以及IgG抗体长期存在，甚至在生命的第44个月仍存在。4名婴儿被诊断为先天性感染；其余婴儿在围产期或之后获得感染。在7例中不能排除输血作为感染源。感染和未感染儿童的临床症状相似。感染儿童肝肿大、脾肿大、高胆红素血症和腹泻的发生率有统计学意义的增加。10名感染儿童发现有先天性异常，包括4例先天性巨细胞症。
