King A J
Division of Nephrology, Tufts University School of Medicine, New England Medical Center, Boston, MA 02111, USA.
Semin Nephrol. 1995 Sep;15(5):405-14.
This article examines the potential role of nitric oxide in the renal hyperfiltration and vasodilation associated with acute amino acid infusions and changes in habitual protein intake. The impact of acute and chronic blockade of nitric oxide synthesis on basal renal hemodynamics and on the renal response to protein are examined. Data linking nitric oxide to other well-characterized modulators of the response to protein are reviewed. New insights into the role of nitric oxide and L-arginine in the pathogenesis of progressive renal injury are examined. The data strongly suggest a role for nitric oxide in the complex physiological reply to protein feeding. Modulation of dietary L-Arg might be an important therapeutic maneuver in the prevention of acute and chronic renal injury.
本文探讨了一氧化氮在与急性氨基酸输注及习惯性蛋白质摄入量变化相关的肾超滤和血管舒张中的潜在作用。研究了一氧化氮合成的急性和慢性阻断对基础肾血流动力学以及肾脏对蛋白质反应的影响。回顾了将一氧化氮与其他已充分表征的蛋白质反应调节因子联系起来的数据。探讨了一氧化氮和L-精氨酸在进行性肾损伤发病机制中的作用的新见解。数据有力地表明一氧化氮在对蛋白质摄入的复杂生理反应中发挥作用。调节膳食L-精氨酸可能是预防急性和慢性肾损伤的一项重要治疗策略。
