[Effect of several derivatives of ortho-hydroxybenzoic acid on the glutamate and ketoglutarate oxidation activity of rat liver mitochondria].

Tests conducted with isolated hepatic mitochondria showed that introduction of acetylsalicylic acid (ASA) to rats in a dose of 300 mg/kg for 5 and 20 days inhibited the oxidation systems of glutamate and alpha-ketoglutarate. This effect depends on the stationary concentration of the compound in the organism. Thus, administration of a high ASA dose (300 mg/kg) for 5 and 20 days, as well as its single administration in doses of 400 or 600 mg/kg had the effect of persistently suppressing the activity of these systems without causing any changes in the degree of the energy-generating conjugation.