Matulis A A, Cherkasskaia M D
Farmakol Toksikol. 1977 Mar-Apr;40(2):203-6.
Tests conducted with isolated hepatic mitochondria showed that introduction of acetylsalicylic acid (ASA) to rats in a dose of 300 mg/kg for 5 and 20 days inhibited the oxidation systems of glutamate and alpha-ketoglutarate. This effect depends on the stationary concentration of the compound in the organism. Thus, administration of a high ASA dose (300 mg/kg) for 5 and 20 days, as well as its single administration in doses of 400 or 600 mg/kg had the effect of persistently suppressing the activity of these systems without causing any changes in the degree of the energy-generating conjugation.
对分离的肝线粒体进行的实验表明，以300毫克/千克的剂量给大鼠注射乙酰水杨酸（ASA）5天和20天，会抑制谷氨酸和α-酮戊二酸的氧化系统。这种作用取决于该化合物在生物体内的稳态浓度。因此，以高剂量（300毫克/千克）给予ASA 5天和20天，以及单次给予400或600毫克/千克的剂量，都有持续抑制这些系统活性的作用，且不会引起能量生成偶联程度的任何变化。
