人类嗜T淋巴细胞病毒1型（HTLV-1）Tax蛋白与核因子κB/κB转录复合物之间的分子相互作用 - Suppr

Molecular interactions between HTLV-1 Tax protein and the NF-kappa B/kappa B transcription complex.

作者信息

Hiscott J, Petropoulos L, Lacoste J

机构信息

Terry Fox Molecular Oncology Group, Abe Stern Cancer Research Laboratory, Lady Davis Institute for Medical Research, Sir Mortimer B, Davis-Jewish General Hospital, Montréal, Canada.

出版信息

Virology. 1995 Dec 1;214(1):3-11. doi: 10.1006/viro.1995.9960.

DOI:10.1006/viro.1995.9960

PMID:8525633

Abstract

摘要

相似文献

Molecular interactions between HTLV-1 Tax protein and the NF-kappa B/kappa B transcription complex.人类嗜T淋巴细胞病毒1型（HTLV-1）Tax蛋白与核因子κB/κB转录复合物之间的分子相互作用

Virology. 1995 Dec 1;214(1):3-11. doi: 10.1006/viro.1995.9960.

Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene.人类I型T细胞白血病病毒Tax蛋白对核因子κB/Rel的激活作用涉及IκBα的磷酸化和降解以及RelA（p65）介导的c-rel基因诱导。

Mol Cell Biol. 1994 Nov;14(11):7377-84. doi: 10.1128/mcb.14.11.7377-7384.1994.

The lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-kappa B in human T-cell lines.

Cytokine. 1993 Jul;5(4):372-8. doi: 10.1016/1043-4666(93)90070-l.

Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation.人类嗜T淋巴细胞病毒1型（HTLV-1）的Tax蛋白会使核因子κB（NF-κB）与κB抑制蛋白α（IκB-α）的复合物不稳定，并诱导NF-κB发生核转位以进行转录激活。

Oncogene. 1995 Mar 16;10(6):1199-207.

Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state.人嗜T淋巴细胞病毒1型（HTLV-1）Tax与IκBα之间的关联取决于IκBα的磷酸化状态。

Virology. 1998 Dec 5;252(1):189-99. doi: 10.1006/viro.1998.9430.

Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.为转变奠定基础：人嗜T淋巴细胞病毒1型Tax蛋白对p53功能的抑制

Front Biosci. 2005 Jan 1;10:919-30. doi: 10.2741/1586.

HTLV-1 Tax enhances NF-kappa B2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100.人类嗜T淋巴细胞病毒1型（HTLV-1）Tax蛋白增强核因子κB2（NF-κB2）的表达，并与p52和p100产物结合，但不抑制p100的抑制功能。

Virology. 1995 Feb 1;206(2):1066-74. doi: 10.1006/viro.1995.1029.

Differential response of NF-kappa B1 p105 and NF-kappa B2 p100 to HTLV-I encoded Tax.核因子κB1 p105和核因子κB2 p100对人嗜T淋巴细胞病毒I型编码的Tax的差异反应

FEBS Lett. 1994 Apr 4;342(2):115-8. doi: 10.1016/0014-5793(94)80483-4.

Human T cell leukemia virus type 1 tax protein increases NF-kappa B dimer formation and antagonizes the inhibitory activity of the I kappa B alpha regulatory protein.人类1型T细胞白血病病毒税蛋白可增加核因子κB二聚体的形成，并拮抗IκBα调节蛋白的抑制活性。

Virology. 1996 Nov 1;225(1):52-64. doi: 10.1006/viro.1996.0574.

A trans-activator Tax of human T-cell leukemia virus type 1 binds to NF-kappa B p50 and serum response factor (SRF) and associates with enhancer DNAs of the NF-kappa B site and CArG box.人类1型T细胞白血病病毒的反式激活因子Tax与核因子-κB p50和血清反应因子（SRF）结合，并与核因子-κB位点和CArG盒的增强子DNA相关联。

Oncogene. 1993 Sep;8(9):2391-7.

引用本文的文献

YTHDF1 and YTHDC1 mA reader proteins regulate HTLV-1 and activity.YTHDF1和YTHDC1 mA阅读器蛋白调节人类嗜T淋巴细胞病毒1型（HTLV-1）及其活性。

J Virol. 2025 Mar 18;99(3):e0206324. doi: 10.1128/jvi.02063-24. Epub 2025 Feb 4.

The four and a half LIM family members are novel interactants of the human T-cell leukemia virus type 1 Tax oncoprotein.这四个半 LIM 家族成员是人类 T 细胞白血病病毒 1 型 Tax 癌蛋白的新型相互作用蛋白。

J Virol. 2013 Jul;87(13):7435-44. doi: 10.1128/JVI.00070-13. Epub 2013 Apr 24.

New insight into the oncogenic mechanism of the retroviral oncoprotein Tax.深入了解逆转录病毒癌蛋白 Tax 的致癌机制。

Protein Cell. 2012 Aug;3(8):581-9. doi: 10.1007/s13238-012-2047-0. Epub 2012 Jul 21.

Molecular determinants of human T-lymphotropic virus type 1 transmission and spread.人类 T 淋巴细胞白血病病毒 1 型传播和扩散的分子决定因素。

Viruses. 2011 Jul;3(7):1131-65. doi: 10.3390/v3071131. Epub 2011 Jul 12.

Move or die: the fate of the Tax oncoprotein of HTLV-1.移动或死亡：HTLV-1 的 Tax 癌蛋白的命运。

Viruses. 2011 Jun;3(6):829-57. doi: 10.3390/v3060829. Epub 2011 Jun 15.

Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53.ATM在1型人类T细胞白血病病毒Tax与p53功能相互作用中作用的遗传学证据。

J Virol. 2001 Jan;75(1):396-407. doi: 10.1128/JVI.75.1.396-407.2001.

Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.人类1型T细胞白血病病毒Tax蛋白诱导核因子-κB的过程涉及IκB激酶α（IKKα）和IKKβ细胞激酶的激活。

Mol Cell Biol. 1998 Sep;18(9):5157-65. doi: 10.1128/MCB.18.9.5157.

Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.1型人类T细胞白血病病毒Tax突变体的差异性转录激活是由与CREB结合蛋白和p300的不同相互作用介导的。

Mol Cell Biol. 1998 Apr;18(4):2392-405. doi: 10.1128/MCB.18.4.2392.

Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein.在表达人T细胞白血病病毒1型Tax蛋白的T淋巴细胞中血管细胞黏附分子-1基因的转录激活。

J Virol. 1997 Nov;71(11):8522-30. doi: 10.1128/JVI.71.11.8522-8530.1997.

Expression status of Tax protein in human T-cell leukemia virus type 1-transformed MT4 cells: recall of MT4 cells distributed by the NIH AIDS Research and Reference Reagent Program.

J Virol. 1997 Sep;71(9):6277-8. doi: 10.1128/JVI.71.9.6277-6278.1997.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Molecular interactions between HTLV-1 Tax protein and the NF-kappa B/kappa B transcription complex.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献