Sergeeva T I, Chirikova E V, Babaĭtseva V A
Zh Mikrobiol Epidemiol Immunobiol. 1995 Sep-Oct(5):9-13.
The effectiveness, both immunological (by an increase in the titers of antitoxins) and protective (by resistance to the inoculation of the absolute lethal dose of infective agents), of the regional (wound) revaccination with tetratoxoid (Clostridium perfringens, C. oedematiens, C. septicum, C. histolyticum) was demonstrated on the experimental model of wound infection (gas gangrene) of guinea pigs. The schedule of rapid immunization with tetratoxoid was developed, which made it possible to create good immunological preparedness (basic immunity) for subsequent revaccination in case of traumas within 6 days. The effectiveness of rapid immunization by the application of tetratoxoid on the wound was shown. This immunization ensured a considered increase in the titers of antitoxins within the first 6 days, which increased the protection of the animals from infection with each of the four causative agents of gas gangrene.
在豚鼠伤口感染（气性坏疽）的实验模型上，证实了用四联类毒素（产气荚膜梭菌、水肿梭菌、败血梭菌、溶组织梭菌）进行局部（伤口）再接种在免疫方面（通过抗毒素滴度升高）和保护方面（通过对感染因子绝对致死剂量接种的抵抗力）的有效性。制定了用四联类毒素快速免疫的方案，该方案能够在6天内为创伤后的后续再接种建立良好的免疫准备（基础免疫力）。显示了通过在伤口上应用四联类毒素进行快速免疫的有效性。这种免疫确保在头6天内抗毒素滴度有明显升高，从而增强了动物对四种气性坏疽病原体中每一种感染的抵抗力。
