Sundblad A S, Tamayo R
Hospital Privado de Comunidad, Mar del Plata, Argentina.
Acta Gastroenterol Latinoam. 1995;25(2):67-72.
Neoplastic development partly depends on a balance between cellular proliferative activity and the eventual suppression of the mechanism of apoptosis. Proliferative activity can be estimated by quantification of KI-67 antigen that appears during phases G1, S, G2 and M of the cellular cycle, whereas apoptosis is shown by the expression of the bcl-2 protein. In this study the expression of KI-67 and bcl-2 antigens was examined in a series of 97 gastric adenocarcinomas, to find out their relations with different clinical and pathological factors. The results showed that the expression of KI-67 was only associated to histological grade and did not have any prognostic significance. On the other hand, there was a better 5 year survival rate when invasion did not go beyond the muscularis propria, there were no lymph node metastases, in the woman and when tumors were located in the antrum. bcl-2 protein was surprisingly negative in all cases albeit of previous descriptions of overexpression of this protein in cases of gastric dysplasia. It is postulated that expression of bcl-2 could appear at an early stage of gastric carcinogenesis and that only a small proportion of malignant tumors would maintain that overexpression.
肿瘤的发生发展部分取决于细胞增殖活性与最终凋亡机制抑制之间的平衡。增殖活性可通过定量细胞周期G1、S、G2和M期出现的KI-67抗原进行评估，而凋亡则通过bcl-2蛋白的表达来体现。在本研究中，对97例胃腺癌进行了KI-67和bcl-2抗原表达检测，以探究它们与不同临床和病理因素的关系。结果显示，KI-67的表达仅与组织学分级相关，并无任何预后意义。另一方面，当浸润未超过固有肌层、无淋巴结转移、患者为女性以及肿瘤位于胃窦部时，5年生存率更高。尽管之前有报道称该蛋白在胃发育异常病例中过表达，但令人惊讶的是，所有病例中的bcl-2蛋白均为阴性。据推测，bcl-2的表达可能出现在胃癌发生的早期阶段，且只有一小部分恶性肿瘤会维持这种过表达。
