Ikeda H, Yoshimoto T, Fujiwara K, Ogawa Y
Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.
Acta Histochem. 1995 Jul;97(3):273-80. doi: 10.1016/S0065-1281(11)80189-3.
The expression of tenascin in 8 cases of normal fetal and adult human pituitary glands and in 51 cases of human pituitary adenomas was investigated immunohistochemically with the use of polyclonal antibodies against human tenascin. The immunohistochemical study demonstrated that tenascin is expressed in both fetal and adult normal epithelial cells of the anterior lobe of pituitary glands and in tumor cells of pituitary adenomas, which suggests that tenascin is synthesized by normal pituitary cells as well as by pituitary adenoma cells. Plurihormonal pituitary adenomas, especially those producing 4 or 5 different hormones, tended to show the highest incidence of positive immunoreactivity for tenascin, suggesting that tenascin may be involved in the aggressive behaviour of plurihormonal adenomas.
利用抗人腱生蛋白的多克隆抗体，通过免疫组织化学方法研究了8例正常胎儿及成人垂体以及51例垂体腺瘤中腱生蛋白的表达情况。免疫组织化学研究表明，腱生蛋白在垂体前叶的胎儿及成人正常上皮细胞以及垂体腺瘤的肿瘤细胞中均有表达，这表明腱生蛋白由正常垂体细胞以及垂体腺瘤细胞合成。多激素垂体腺瘤，尤其是那些分泌4种或5种不同激素的腺瘤，腱生蛋白阳性免疫反应的发生率往往最高，这表明腱生蛋白可能与多激素腺瘤的侵袭性行为有关。
