Cummings J F, de Lahunta A, Mohammed H O, Divers T J, Summers B A, Valentine B A, Jackson C A
Department of Anatomy, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA.
Acta Neuropathol. 1995;90(3):266-72. doi: 10.1007/BF00296510.
Two spontaneous neurodegenerative diseases of the horse, equine motor neuron disease (EMND) and equine degenerative myeloencephalopathy (EDM), have been associated with alpha-tocopherol deficiency, and both were characterized by prominent accumulations of endothelial lipopigment in the small vessels of the spinal cord. These endothelial pigment deposits appear to be reversible. In EMND horses pasture-supplemented for 9 months or more after the progression of weakness and wasting had arrested, there was very little endothelial lipopigment. The origin and the potential effects of these endothelial lipopigment accumulations are discussed.
