Boeynaems J M, Dumont J E
Mol Cell Endocrinol. 1977 Mar;7(1):33-47. doi: 10.1016/0303-7207(77)90074-0.
The theoretical properties of a "two-step" receptor, consisting of two independent molecular entities, a regulatory (R) and an effector (E) unit, which are supposed to diffuse freely in the plane of the fluid and mosaic membrane, are presented. The ligand (L)-hormone, drug, neurotransmitter-binds to the regulatory unit (first step), so that it then becomes able to interact with the effector unit (second step) which is then activated.
本文介绍了一种“两步式”受体的理论特性，该受体由两个独立的分子实体组成，即调节（R）单元和效应器（E）单元，假定它们在流体镶嵌膜平面内可自由扩散。配体（L）——激素、药物、神经递质——与调节单元结合（第一步），从而使其能够与随后被激活的效应器单元相互作用（第二步）。
