Archimandritis A, Sipsas N, Tryphonos M, Tsirantonaki M, Tjivras M
Department of Pathologic Physiology, Laikon General Hospital, University of Athens, Medical School, Greece.
Ann Med Interne (Paris). 1995;146(5):299-303.
This prospective study was undertaken to evaluate the significance of factors such as age, sex family history, educational status, residence area, H pylori antral colonization, smoking, alcohol consumption, coffee and cola drinking in Greek patients suffering from functional dyspepsia (FD), duodenal ulcer (DU), and gastric ulcer (GU). The study groups were chosen among consecutive outpatients who had undergone an upper gastro-intestinal (GI) endoscopy during a ten-month period because of dyspepsia, and who completed a suitable questionnaire; 295 patients aged 18-85 years (M: 185, F: 110) were finally included as follows: 54 patients aged 18-80 years M: 21, F: 33) with FD, 166 aged 19-85 years (M: 117, F: 49) with DU, and 75 aged 24-85 years (M: 47, F: 28) with GU. As controls for FD patients, 54 previously studied, healthy non-dyspeptic people, well matched for age and sex, were used. No differences were found between them and FD patients. On the contrary, we found that the 3 groups of patients differed significantly for age (p = 1.07 x 10(-3)) and sex (p = 1.67 x 10(-4)) distribution. There was a rather even age distribution and a discrete female predominance in the FD group. Positive family history for peptic ulcer disease (PUD) was found in 19% of patients with FD as compared with 48.2% (DU) and 37% (GU) (p = 4.84 x 10(-4)). Significantly more patients with PUD were smokers (p = 6.16 x 10(-3)) and alcohol drinkers (p = 1.84 x 10(-4)). H pylori antral colonization was found in 61% of patients with FD as compared with 74% (GU) and 85% (DU) (p = 8.65 x 10(-4)) of patients. Finally, factors such as educational level, area of residence, and cola drink consumption did not differ in the studied groups of patients.
本前瞻性研究旨在评估年龄、性别、家族史、教育程度、居住地区、幽门螺杆菌胃窦部定植、吸烟、饮酒、饮用咖啡和可乐等因素对患有功能性消化不良（FD）、十二指肠溃疡（DU）和胃溃疡（GU）的希腊患者的意义。研究组从连续十个月因消化不良接受上消化道（GI）内镜检查并完成合适问卷的门诊患者中选取；最终纳入295名年龄在18 - 85岁的患者（男：185名，女：110名），具体如下：54名年龄在18 - 80岁的患者（男：21名，女：33名）患有FD，166名年龄在19 - 85岁的患者（男：117名，女：49名）患有DU，75名年龄在24 - 85岁的患者（男：47名，女：28名）患有GU。作为FD患者的对照，使用了54名先前研究过的、年龄和性别匹配良好的健康无消化不良者。在他们与FD患者之间未发现差异。相反，我们发现三组患者在年龄（p = 1.07×10⁻³）和性别（p = 1.67×10⁻⁴）分布上有显著差异。FD组年龄分布较为均匀，女性占主导。FD患者中19%有消化性溃疡病（PUD）家族史阳性，而DU患者为48.2%，GU患者为37%（p = 4.84×10⁻⁴）。PUD患者中吸烟者（p = 6.16×10⁻³）和饮酒者（p = 1.84×10⁻⁴）明显更多。FD患者中61%发现幽门螺杆菌胃窦部定植，而GU患者为74%，DU患者为85%（p = 8.65×10⁻⁴）。最后，教育水平、居住地区和可乐饮用等因素在研究的患者组中无差异。
