Pélissolo A, Héloire F
Service de Psychiatrie, Hôpital Fernand-Widal, Paris.
Ann Med Psychol (Paris). 1995 Aug-Sep;153(7):441-7.
More than 25 years of the use of systemic beta-blockers in cardiovascular pathologies, but also in various other indications, have yielded a number of reports suggesting that these drugs was linked with the development of clinical depression. Some retrospective studies have been carried out with positive results, but the rare longitudinal prospective studies have failed to confirm the association between beta-blockers use and depression. Clinical, methodological and pharmacological problems may explain these discrepancies and are of great interest.
在心血管疾病以及其他各种适应症中使用全身性β受体阻滞剂已有25年以上，期间有许多报告表明这些药物与临床抑郁症的发生有关。已经开展了一些回顾性研究，结果呈阳性，但罕见的纵向前瞻性研究未能证实使用β受体阻滞剂与抑郁症之间的关联。临床、方法学和药理学问题可能解释了这些差异，并且这些问题非常值得关注。
