Loisance D, Mazzucotelli J P, Benvenuti C, Le Besnerais P, Mourtada A, Aptecar E, Pouillard F, Deleuze P H, Hillion M L, Cachera J P
Service de chirurgie thoracique et cardiovasculaire, hôpital Henri-Mondor, Créteil.
Arch Mal Coeur Vaiss. 1995 Sep;88(9):1273-6.
After cardiac transplantation, long-term results were assessed in a group of 46 patients who survived more than 5 years after surgery. They were the survivors (50%) of a group of 92 patients who underwent transplantation before January 1990. On January 1995, mean follow-up was 82 +/- 14 months. Quality of life was estimated satisfactory (mean score 8.4 +/- 2); 60% of the patients were active; 89% were class NYHA I or II. Nevertheless, several problems have been identified: rise in body weight for all, over 10 kg in 31%; hypertension, renal failure, considered to be severe (serum creatinine > 250 micrograms/l) in 26%, diabetes in 13%, osteoarthropathy in 33%, cancer in 6%, and, above all, chronic alteration of the coronary arterial bed in 53% of the patients. These problems reflect the immunological conflict and complications of immuno-suppression.
心脏移植术后，对一组术后存活超过5年的46例患者进行了长期结果评估。他们是1990年1月前接受移植的92例患者中的幸存者（50%）。1995年1月，平均随访时间为82±14个月。生活质量评估为满意（平均得分8.4±2）；60%的患者活动自如；89%的患者为纽约心脏协会（NYHA）I级或II级。然而，也发现了一些问题：所有患者体重均增加，31%的患者体重增加超过10公斤；26%的患者患有高血压、被认为严重的肾衰竭（血清肌酐>250微克/升），13%的患者患有糖尿病，33%的患者患有骨关节炎，6%的患者患有癌症，最重要的是，53%的患者存在冠状动脉床慢性病变。这些问题反映了免疫冲突和免疫抑制的并发症。
