Bürgisser D M, Siegenthaler G, Kuster T, Hellman U, Hunziker P, Birchler N, Heizmann C W
Department of Pediatrics, University of Zurich, Switzerland.
Biochem Biophys Res Commun. 1995 Dec 5;217(1):257-63. doi: 10.1006/bbrc.1995.2772.
The Ca(2+)-binding proteins regulate a number of cellular and extracellular activities and deregulations of S100 gene expression are associated with several human diseases. For example, S100A7 is upregulated in psoriatic skin, implicating a link with psoriasis, a chronic inflammatory dermatosis. We purified human S100A7 and determined its protein sequence by tandem mass spectrometry and Edman microsequence analysis. Interestingly, a sequence comparison of S100A7 with all known human S100 proteins showed that S100A7 is the most divergent of all S100 proteins.
钙离子结合蛋白调节许多细胞内和细胞外活动，S100基因表达失调与多种人类疾病相关。例如，S100A7在银屑病皮肤中上调，这表明它与银屑病（一种慢性炎症性皮肤病）存在关联。我们纯化了人S100A7，并通过串联质谱和埃德曼微量序列分析确定了其蛋白质序列。有趣的是，将S100A7与所有已知的人类S100蛋白进行序列比较后发现，S100A7是所有S100蛋白中差异最大的。
