Charpin C, Allasia C, Davies J D, Devictor B, Boulat J, Ansaldi J L, Lavaut M N, Serradour B, Andrac L, Piana L
Department of Pathology, Centre Hospitale Universitaire Timone, France.
Anal Quant Cytol Histol. 1995 Aug;17(4):230-40.
A series of 104 nonpalpable breast lesions detected by mammograms and containing microcalcifications were studied. Intraoperative radiographs of intact and sliced specimens were assessed, followed by microscopic diagnosis on frozen sections of areas containing microcalcifications. Microcalcifications detected on mammograms and radiographs of the specimens were digitized and evaluated in accordance with morphometric parameters, including the mean surface, shape factor, bend energy, envelope surface and total surface, total number and concentration of microcalcifications. Benign disorders, atypical hyperplasia and carcinomas accounted for 47.2%, 4.8% and 48% of the tissue lesions, respectively, but the disorders were most often heterogeneous and mixed. Most, but not all, parameters significantly correlated with the three types of radiographs, although radiographs of the sliced specimens provided images of the best quality. Only two parameters, mean size and bend energy, were significantly different (P = .008, .0036) in benign and malignant lesions. It is concluded that image analysis of digitized microcalcifications in radiographs may provide quantitative data helpful in mammogram interpretation.
对104例通过乳房X线照片检测出的、含有微钙化的不可触及乳腺病变进行了研究。对完整标本和切片标本的术中X线照片进行评估，随后对含有微钙化区域的冰冻切片进行显微镜诊断。对乳房X线照片和标本的X线照片上检测到的微钙化进行数字化处理，并根据形态计量学参数进行评估，这些参数包括平均面积、形状因子、弯曲能量、包络面积和总面积、微钙化的总数和浓度。良性病变、非典型增生和癌分别占组织病变的47.2%、4.8%和48%，但这些病变大多是异质性和混合性的。大多数（但不是全部）参数与三种类型的X线照片显著相关，尽管切片标本的X线照片提供了质量最好的图像。在良性和恶性病变中，只有平均大小和弯曲能量这两个参数有显著差异（P = 0.008，0.0036）。结论是，对X线照片中数字化微钙化的图像分析可能提供有助于乳房X线照片解读的定量数据。
