Gust V R, Weber R, Henn-Beilharz A, Krier C
Klinik für Anaesthesiologie, Universität Heidelberg.
Anaesthesiol Reanim. 1995;20(5):134-8.
Patient-controlled analgesia (PCA) is a well-accepted technique in postoperative pain management. We used PCA in three different protocols to find the optimum application form. Our study compared 100 patients with radical prostatectomy or transperitoneal tumor nephrectomy in three groups using piritramide. Group 1 (n = 16) received 1.2 mg/h continuously and a 3 mg bolus with a lock-out time of 90 min. Group 2 (n = 30) received 0.8 mg/h continuously and a 3 mg bolus with a lock-out time of 60 min. Group 3 (n = 54) received the same continuous infusion, but the lock-out time was only 30 min. After 24 hours we evaluated the quality of analgesia using VAS scale. The quantity of piritramide was equal in all groups (35.1 mg). An average of seven bolus applications were made during the observation period. In 27.6% of the patients (group 1: 30.4%; group 2: 35.0%; group 3: 23.1%) the bolus demand was refused by programme. The analgesia level was satisfactory in each group, with a VAS value of 27. There was no respiratory depression observed. In conclusion, on-demand analgesia proved to be a good and practicable method in postoperative pain management. Although the dosage of piritramide was not different in the three groups, we recommend the protocol of group 3 because of the lower refusal of bolus application. Therefore, this seems to be the best patient-adapted application form. Even though respiratory complications in the group 3 scheme are not expected, monitoring of respiration and vigilance are recommended.
患者自控镇痛(PCA)是术后疼痛管理中一种广为接受的技术。我们采用三种不同方案使用PCA以找出最佳应用形式。我们的研究比较了100例行根治性前列腺切除术或经腹肿瘤肾切除术的患者,三组均使用匹米诺定。第一组(n = 16)持续接受1.2 mg/h的剂量,并给予3 mg的单次推注剂量,锁定时间为90分钟。第二组(n = 30)持续接受0.8 mg/h的剂量,并给予3 mg的单次推注剂量,锁定时间为60分钟。第三组(n = 54)接受相同的持续输注剂量,但锁定时间仅为30分钟。24小时后,我们使用视觉模拟评分法(VAS)评估镇痛质量。所有组的匹米诺定用量相同(35.1 mg)。在观察期内平均进行了7次单次推注。27.6%的患者(第一组:30.4%;第二组:35.0%;第三组:23.1%)的单次推注需求被程序拒绝。每组的镇痛水平均令人满意,VAS值为27。未观察到呼吸抑制。总之,按需镇痛在术后疼痛管理中被证明是一种良好且可行的方法。尽管三组的匹米诺定剂量没有差异,但由于单次推注的拒绝率较低,我们推荐第三组的方案。因此,这似乎是最适合患者的应用形式。尽管预计第三组方案中不会出现呼吸并发症,但仍建议监测呼吸并保持警惕。