Bodis-Wollner I, Borod J C, Cicero B, Haywood C S, Raskin S, Mylin L, Sliwinski M, Falk A, Yahr M D
Department of Neurology, State University of New York, Brooklyn, USA.
J Neural Transm Park Dis Dement Sect. 1995;9(2-3):197-209. doi: 10.1007/BF02259661.
The relationship between event-related potentials (ERPs) and cognitive functioning was studied in patients with Parkinson's Disease (PD) but without dementia. Auditory and visual stimuli were used; 30 subjects participated in the auditory study and 20 in the visual study. Patient groups did not differ with respect to gender, age, education, illness duration, and level of cognitive functioning. Visual stimuli were 2.3 cpd sinusoidal grating patterns randomly presented in an oddball paradigm (oblique vs. vertical spatial orientation). Auditory stimuli were tones presented at 70 dB SPL at a rate of 1.1/second, also using the oddball paradigm (1.5K vs. 1K tones). All patients were given neuropsychological tests to measure verbal fluency, memory, visual spatial perception, and abstract reasoning. P300 and N200 abnormalities correlated with a number of these measures, such that longer ERP latencies were related to lower scores on tests of cognitive functioning. Patterns of results suggest that auditory and visual ERPs correlate with different subsets of neuropsychological functions in nondemented PD patients and that N200 may provide a new metric for clinical use.
在无痴呆的帕金森病（PD）患者中研究了事件相关电位（ERP）与认知功能之间的关系。使用了听觉和视觉刺激；30名受试者参与了听觉研究，20名参与了视觉研究。患者组在性别、年龄、教育程度、病程和认知功能水平方面没有差异。视觉刺激是在奇偶数范式（倾斜与垂直空间方向）中随机呈现的2.3周/度正弦光栅图案。听觉刺激是以70分贝声压级、每秒1.1次的速率呈现的音调，同样使用奇偶数范式（1.5千赫兹与1千赫兹音调）。所有患者都接受了神经心理学测试，以测量语言流畅性、记忆力、视觉空间感知和抽象推理能力。P300和N200异常与其中多项测量指标相关，因此ERP潜伏期延长与认知功能测试得分较低有关。结果模式表明，在无痴呆的PD患者中，听觉和视觉ERP与不同的神经心理学功能子集相关，并且N200可能为临床应用提供一种新的指标。
