Stability-indicating high performance liquid chromatographic method for determination of norfloxacin in bulk form and tablets.

作者信息

al-Deeb O A, Abdel-Moety E M, Abounassif M A, Alzaben S R

机构信息

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

出版信息

Boll Chim Farm. 1995 Oct;134(9):497-502.

PMID:8527102

Abstract

High performance liquid chromatographic (HPLC) separation has been investigated for the determination of intact norfloxacin in the presence of its photodegradation products. The HPLC-separation could be achieved isocratically and by gradient elution on a Micropak -NH2 column (10 microns, 30 cm x 4 mm O) using a mobile phase containing acetonitrile, tetrabutylammonium hydroxide, o-phosphoric acid and water at a rate of 2 ml.min-1 with UV-detection (278 nm) at ambient temperature. The method was applied for the drug analysis in fresh and photodegraded norfoxacin samples, as well as for assessment of the content uniformity of tablets containing the drug. The results of the proposed liquid chromatographic method were statistically matched with those obtained by adopting an official HPLC-method (USP XXII-procedure).

摘要

相似文献

Stability-indicating high performance liquid chromatographic method for determination of norfloxacin in bulk form and tablets.

Boll Chim Farm. 1995 Oct;134(9):497-502.

Development and validation of a stability-indicating high performance liquid chromatographic (HPLC) assay for biperiden in bulk form and pharmaceutical dosage forms.用于原料药及制剂中比哌立登的稳定性指示高效液相色谱（HPLC）测定法的开发与验证

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jul 1;854(1-2):152-7. doi: 10.1016/j.jchromb.2007.04.016. Epub 2007 Apr 19.

Separation and determination of synthetic impurities of norfloxacin by reversed-phase high performance liquid chromatography.用反相高效液相色谱法分离和测定诺氟沙星的合成杂质。

J Pharm Biomed Anal. 2004 Mar 10;34(5):1049-56. doi: 10.1016/j.jpba.2003.11.009.

High performance liquid chromatographic and thin layer densitometric methods for the determination of risperidone in the presence of its degradation products in bulk powder and in tablets.高效液相色谱法和薄层光密度法用于测定原料药粉末和片剂中存在降解产物情况下的利培酮含量。

J Pharm Biomed Anal. 2005 Jan 4;36(5):975-81. doi: 10.1016/j.jpba.2004.07.014.

Validated stability-indicating HPLC method for the determination of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) and its degradation products.验证的稳定性指示高效液相色谱法测定4,4'-二甲氧基-5,6,5',6'-二亚甲基二氧基联苯-2,2'-二甲酸二甲酯（DDB）及其降解产物。

J Pharm Biomed Anal. 2008 Aug 5;47(4-5):695-703. doi: 10.1016/j.jpba.2008.02.017. Epub 2008 Feb 26.

A stability-indicating high performance liquid chromatographic (HPLC) assay for the simultaneous determination of atorvastatin and amlodipine in commercial tablets.一种用于同时测定市售片剂中阿托伐他汀和氨氯地平的稳定性指示高效液相色谱（HPLC）分析方法。

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Feb 1;846(1-2):215-21. doi: 10.1016/j.jchromb.2006.09.007. Epub 2006 Sep 28.

Development and validation of a reversed-phase ion-pair high-performance liquid chromatographic method for the determination of risedronate in pharmaceutical preparations.用于测定药物制剂中利塞膦酸盐的反相离子对高效液相色谱法的开发与验证

Anal Chim Acta. 2007 Feb 12;584(1):153-9. doi: 10.1016/j.aca.2006.11.012. Epub 2006 Nov 11.

Stability-indicating methods for the determination of piretanide in presence of the alkaline induced degradates.在碱性诱导降解产物存在的情况下测定吡咯他尼的稳定性指示方法。

J Pharm Biomed Anal. 2005 Oct 4;39(5):871-6. doi: 10.1016/j.jpba.2005.02.035. Epub 2005 Apr 22.

Validation of a high-performance liquid chromatographic method for the determination of norfloxacin and its application to stability studies (photo-stability study of norfloxacin).一种用于测定诺氟沙星的高效液相色谱方法的验证及其在稳定性研究中的应用（诺氟沙星的光稳定性研究）

J Pharm Biomed Anal. 1999 Jan;18(6):919-26. doi: 10.1016/s0731-7085(98)00037-5.

A validated RP-HPLC method for the determination of mosapride citrate in bulk drug samples and pharmaceutical formulations.一种用于测定原料药样品和药物制剂中枸橼酸莫沙必利的经过验证的反相高效液相色谱法。

Pharmazie. 2002 Dec;57(12):814-6.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验