Queizán A, García-Miguel P, Belló M J, Castresana J C, Rey J A, Pestaña A
Departamento de Cirugía Pediátrica, Hospital Infantil La Paz, Madrid.
Cir Pediatr. 1995 Jul;8(3):96-8.
Several biologic features of tumor cells correlate closely with a favorable or unfavorable outcome. To aid in assessing correlation in the various number of prognostic factors including the age, stage, VMA/HVA ratios, and the serum levels of NSE and ferritin, the histopathological features, ploidy, partial monosomy for the short arm of chromosome 1, and the tumor N-myc gene copy number, are examined. We determined the sensitivity and specificity of classical markers above the amplification of the N-myc oncogene. A striking new observation is the positive correlation between genomic amplification and some prognostic factors (stage, ferritin, NSE, pathologic anatomy and 1p deletion.
肿瘤细胞的几种生物学特征与预后的好坏密切相关。为了有助于评估包括年龄、分期、香草扁桃酸/高香草酸比值以及神经元特异性烯醇化酶和铁蛋白血清水平等多种预后因素之间的相关性，我们检测了组织病理学特征、倍性、1号染色体短臂部分单体性以及肿瘤N - myc基因拷贝数。我们确定了N - myc癌基因扩增以上经典标志物的敏感性和特异性。一个引人注目的新发现是基因组扩增与一些预后因素（分期、铁蛋白、神经元特异性烯醇化酶、病理解剖和1p缺失）之间呈正相关。
