烟酰胺腺嘌呤二核苷酸（NAD）、多聚腺苷二磷酸核糖（poly ADP-核糖）和环磷酸腺苷二磷酸核糖（cyclic ADP-核糖）生理意义的新进展
New aspects of the physiological significance of NAD, poly ADP-ribose and cyclic ADP-ribose.
作者信息
Okamoto H, Takasawa S, Tohgo A
机构信息
Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan.
出版信息
Biochimie. 1995;77(5):356-63. doi: 10.1016/0300-9084(96)88146-6.
PMID:8527489
Abstract
Cyclic ADP-ribose is generated from NAD+ in glucose-stimulated beta-cells by CD38. Cyclic ADP-ribose mobilizes Ca2+ from the endoplasmic reticulum to secrete insulin. The amino acid residues of Cys-119 and Cys-201 in CD38 are essential for the synthesis and hydrolysis of cyclic ADP-ribose.
摘要
在葡萄糖刺激的β细胞中，环磷酸腺苷核糖由CD38从烟酰胺腺嘌呤二核苷酸（NAD+）生成。环磷酸腺苷核糖从内质网动员钙离子以分泌胰岛素。CD38中半胱氨酸-119和半胱氨酸-201的氨基酸残基对于环磷酸腺苷核糖的合成和水解至关重要。
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