Zheng Y, Doerschuk P C, Johnson J E
School of Electrical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
Biophys J. 1995 Aug;69(2):619-39. doi: 10.1016/S0006-3495(95)79939-8.
The capsid is modeled as a region of constant electron density located between inner and outer envelopes that exhibit icosahedral symmetry. For computational purposes the envelopes are represented as truncated sums of weighted icosahedral harmonics. Methods are described for estimating the weights from x-ray solution scattering patterns based on nonlinear least squares, and two examples of the procedure, for viruses with known atomic-resolution structures, are given.
衣壳被建模为位于具有二十面体对称性的内外包膜之间的恒定电子密度区域。出于计算目的，包膜表示为加权二十面体谐波的截断和。描述了基于非线性最小二乘法从X射线溶液散射图案估计权重的方法，并给出了该程序的两个示例，用于具有已知原子分辨率结构的病毒。
