Torres G
Department of Psychology, State University of New York at Buffalo 14260-4110, USA.
Neuroreport. 1995 Aug 21;6(12):1679-83. doi: 10.1097/00001756-199508000-00021.
Systemic administration of DL-fenfluramine (20 mg kg-1), an indirect serotonergic agonist, induced widespread FOS-like protein in the rat caudate putamen (CPu), paraventricular nucleus (PVn) of the hypothalamus and several intralaminar thalamic nuclei. To ascertain whether the dopaminergic nigrostriatal system coordinated transcriptional effects on the CPu, discrete microinjections of dextran into the substantia nigra (cell group A9) were evaluated for retrograde axonal transport. The protein product was induced preferentially in medium-sized spiny nerve cells of the CPu. Dextran microinjections into the PVn demonstrated that perikarya bearing FOS-like protein projected their extensions directly to thalamic nuclei and indirectly to immunopositive neurons of the striatum. The significance of these latter results is discussed in terms of a possible dopaminergic mechanism.
给予大鼠间接5-羟色胺能激动剂DL-芬氟拉明（20毫克/千克）进行全身给药后，在大鼠尾状壳核（CPu）、下丘脑室旁核（PVn）以及几个丘脑板内核中诱导出广泛的FOS样蛋白。为确定多巴胺能黑质纹状体系统是否协调对CPu的转录作用，评估了向黑质（细胞群A9）中离散微量注射葡聚糖的逆行轴突运输情况。蛋白产物优先在CPu的中型棘状神经细胞中诱导产生。向PVn中微量注射葡聚糖表明，带有FOS样蛋白的核周体将其延伸直接投射到丘脑核，并间接投射到纹状体的免疫阳性神经元。根据可能的多巴胺能机制对后一结果的意义进行了讨论。
