Zangemeister W H, von Windheim K
Fortschr Med. 1977 Apr 28;95(16):1095-100.
Paraneoplastic neurologic syndromes in patients suffering from bronchial carcinoma were found by Croft and Wilkinson (Croft et al. 1965, Croft and Wilkinson 1965) in 16%. We examined the question whether in patients suffering from bronchial carcinoma neurologic syndromes are as frequent as in a comparative group of patients with different bronchial diseases. Out of 99 patients 61 had histological proof of bronchial carcinoma, 38 were suffering from chronic inflammatory bronchial diseases. The groups were statistically comparable to each other. Cases with carcinoma in situ (TINOMO) showed no significant difference from patients without bronchial carcinoma. In patients who showed intrathoracic metastases of lymphatic ganglions we found neurologic syndromes in 31% (p less than 0.01). Differing from the extension of tumor metastases there was no correlation between duration and frequency of neurologic syndromes. This corresponds to the experience of our hospital in the last 10 years; 5.7% of all patients with extracerebral tumors showed neurologic syndromes, most frequently polyneuropathies. In 10-15% of a normal population one can find these symptoms (Skre 1972), this means they are polygenetic. We did not find frequently an oat cell carcinoma in our material. Cases in which the neuromyopathy preceeded the manifestation of the bronchial carcinoma were not seen. Altogether it can be stated that paraneoplastic neuromyopathies in patients suffering from bronchial carcinoma are more seldom than it was to be assumed from the anglo-saxon literature.
克罗夫特和威尔金森（克罗夫特等人，1965年；克罗夫特和威尔金森，1965年）发现，16%的支气管癌患者会出现副肿瘤性神经综合征。我们研究了支气管癌患者中神经综合征的发生率是否与一组患有不同支气管疾病的对照患者一样高。在99例患者中，61例有支气管癌的组织学证据，38例患有慢性炎症性支气管疾病。两组在统计学上具有可比性。原位癌（TINOMO）病例与无支气管癌的患者无显著差异。在出现胸内淋巴结转移的患者中，我们发现31%的患者有神经综合征（p<0.01）。与肿瘤转移的范围不同，神经综合征的持续时间和发生率之间没有相关性。这与我们医院过去10年的经验相符；所有脑外肿瘤患者中有5.7%出现神经综合征，最常见的是多发性神经病。在10% - 15%的正常人群中可以发现这些症状（斯克雷，1972年），这意味着它们是多基因的。我们的研究材料中未频繁发现燕麦细胞癌。未见到神经肌肉病先于支气管癌出现的病例。总体而言，可以说支气管癌患者中的副肿瘤性神经肌肉病比盎格鲁 - 撒克逊文献中所推测的更为少见。
