Kovács T, Barta J, Kocsis B, Nagy J
Nephrology Center of Second Department of Medicine, University Medical School of Pécs, Hungary.
Exp Nephrol. 1995 Nov-Dec;3(6):369-72.
Nitric oxide (NO) is claimed to have a role in the pathogenesis of immune-mediated glomerulonephritis and in the regulation of blood pressure (BP). NO rapidly converts to NO2-/NO3- which is excreted in the urine. We determined the daily NO2-/NO3- excretion in 26 IgA nephropathy (NP) patients and 20 healthy controls, recording the BP in each. There was no difference in NO2-/NO3- excretion between IgA NP patients and controls (999.1 +/- 66.8 vs. 1,051.2 +/- 53.0 mumol/day). The urinary excretion of NO2-/NO3- in IgA NP patients whose mean diastolic BP remained above 85 mm Hg in spite of antihypertensive therapy, was significantly decreased (n = 8; 734.38 +/- 87.83 mumol/day; p < 0.05). There was a significant inverse correlation between mean diastolic BP and urinary NO2-/NO3- (p < 0.006). NO2-/NO3- excretion decreased with aging (p < 0.01) in IgA NP patients, but not in controls. The fact that there was no difference between the urinary NO2-/NO3- excretion of IgA NP patients and controls argues against the idea that NO production in immune-mediated IgA NP can be increased. The decrease of urinary NO2-/NO3- in hypertensive and in older IgA NP patients may be correlated with the impaired NO production of the endothelium.
一氧化氮（NO）被认为在免疫介导性肾小球肾炎的发病机制以及血压（BP）调节中起作用。NO会迅速转化为NO2-/NO3-，并通过尿液排出。我们测定了26例IgA肾病（NP）患者和20名健康对照者的每日NO2-/NO3-排泄量，并记录了每个人的血压。IgA肾病患者与对照组之间的NO2-/NO3-排泄量没有差异（999.1±66.8对1,051.2±53.0μmol/天）。尽管进行了抗高血压治疗，但平均舒张压仍高于85 mmHg的IgA肾病患者的尿NO2-/NO3-排泄量显著降低（n = 8；734.38±87.83μmol/天；p < 0.05）。平均舒张压与尿NO2-/NO3-之间存在显著的负相关（p < 0.006）。在IgA肾病患者中，NO2-/NO3-排泄量随年龄增长而降低（p < 0.01），但在对照组中并非如此。IgA肾病患者与对照组的尿NO2-/NO3-排泄量没有差异这一事实，反驳了免疫介导的IgA肾病中NO生成会增加的观点。高血压和老年IgA肾病患者尿NO2-/NO3-的降低可能与内皮细胞NO生成受损有关。
