Delville Y, Conklin L S, Ferris C F
Psychiatry Department, University of Massachusetts Medical Center, Worcester 01655, USA.
Brain Res. 1995 Aug 14;689(1):147-50. doi: 10.1016/0006-8993(95)00536-y.
Vasopressin (AVP) receptor binding within hypothalamic sites was compared between cycling and lactating female golden hamsters. The density of AVP receptor binding was analyzed by quantitative autoradiography within the ventrolateral hypothalamus and dorsomedial hypothalamic nucleus. Lactation was correlated with a disappearance of AVP receptor binding within the ventrolateral hypothalamus. In contrast, lactation was associated with a two- to three-fold increase in the density of AVP receptor binding within the dorsomedial hypothalamic nucleus. These results suggest that AVP receptor binding within the ventrolateral hypothalamus is responsive to gonadal hormones in female golden hamsters. However, the increase in binding observed within the dorsomedial hypothalamus may be related to other neurobiological changes associated with lactation.
对处于发情周期和哺乳期的雌性金黄地鼠下丘脑部位的血管加压素（AVP）受体结合情况进行了比较。通过定量放射自显影分析腹外侧下丘脑和背内侧下丘脑核内AVP受体结合的密度。哺乳期与腹外侧下丘脑内AVP受体结合的消失相关。相反，哺乳期与背内侧下丘脑核内AVP受体结合密度增加两到三倍相关。这些结果表明，雌性金黄地鼠腹外侧下丘脑内的AVP受体结合对性腺激素有反应。然而，在背内侧下丘脑内观察到的结合增加可能与哺乳期相关的其他神经生物学变化有关。
