Interleukin-7, interleukin-12, and GM-CSF gene transfer in patients with metastatic melanoma.

Suppr

超能文献

作者信息

Schadendorf D, Czarnetzki B M, Wittig B

机构信息

Virchow-Klinik, Dermatologie, Humboldt Universität Berlin, Germany.

出版信息

J Mol Med (Berl). 1995 Sep;73(9):473-7. doi: 10.1007/BF00202266.

DOI:10.1007/BF00202266

PMID:8528751

Abstract

摘要

相似文献

Interleukin-7, interleukin-12, and GM-CSF gene transfer in patients with metastatic melanoma.

J Mol Med (Berl). 1995 Sep;73(9):473-7. doi: 10.1007/BF00202266.

Phase I/IB study of immunization with autologous tumor cells transfected with the GM-CSF gene by particle-mediated transfer in patients with melanoma or sarcoma.采用颗粒介导转移法用转染GM-CSF基因的自体肿瘤细胞进行免疫接种的I期/Ib期研究，对象为黑色素瘤或肉瘤患者。

Hum Gene Ther. 1997 May 1;8(7):875-91. doi: 10.1089/hum.1997.8.7-875.

Therapeutic vaccination against metastatic carcinoma by expression-modulated and immunomodified autologous tumor cells: a first clinical phase I/II trial.通过表达调控和免疫调节的自体肿瘤细胞进行转移性癌的治疗性疫苗接种：首个临床I/II期试验

Hum Gene Ther. 2001 Feb 10;12(3):267-78. doi: 10.1089/10430340150218404.

Intralesional vaccinia/GM-CSF recombinant virus in the treatment of metastatic melanoma.病灶内注射牛痘/GM-CSF重组病毒治疗转移性黑色素瘤。

Adv Exp Med Biol. 2000;465:391-400. doi: 10.1007/0-306-46817-4_34.

Human autologous in vitro models of glioma immunogene therapy using B7-2, GM-CSF, and IL12.使用B7-2、粒细胞-巨噬细胞集落刺激因子（GM-CSF）和白细胞介素12（IL12）的人胶质瘤免疫基因治疗自体体外模型

Can J Neurol Sci. 2002 Aug;29(3):267-75. doi: 10.1017/s0317167100002055.

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma.用经基因工程改造以分泌人粒细胞巨噬细胞集落刺激因子的辐照自体黑色素瘤细胞进行疫苗接种，可在转移性黑色素瘤患者中产生强大的抗肿瘤免疫力。

Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13141-6. doi: 10.1073/pnas.95.22.13141.

Adoptive immunotherapy of cancer with activated lymph node cells primed in vivo with autologous tumor cells transduced with the GM-CSF gene.采用经GM-CSF基因转导的自体肿瘤细胞在体内致敏的活化淋巴结细胞进行癌症的过继性免疫治疗。

Hum Gene Ther. 1996 Apr 10;7(6):773-92. doi: 10.1089/hum.1996.7.6-773.

Increased non-major histocompatibility complex-restricted lytic activity in melanoma patients vaccinated with cytokine gene-transfected autologous tumor cells.用细胞因子基因转染的自体肿瘤细胞接种的黑色素瘤患者中，非主要组织相容性复合体限制的溶解活性增加。

Cancer Gene Ther. 2000 Jul;7(7):976-84. doi: 10.1038/sj.cgt.7700203.

Technical hurdles in a pilot clinical trial of combined B7-2 and GM-CSF immunogene therapy for glioblastomas and melanomas.B7-2与GM-CSF联合免疫基因疗法治疗胶质母细胞瘤和黑色素瘤的初步临床试验中的技术障碍。

J Neurooncol. 2006 May;78(1):71-80. doi: 10.1007/s11060-005-9058-0. Epub 2006 Apr 21.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by cDNA-transfected tumor cells induces a more potent antitumor response than exogenous GM-CSF.由cDNA转染的肿瘤细胞分泌的粒细胞-巨噬细胞集落刺激因子（GM-CSF）比外源性GM-CSF诱导更强有力的抗肿瘤反应。

Cancer Gene Ther. 1999 Jan-Feb;6(1):81-8. doi: 10.1038/sj.cgt.7700012.

引用本文的文献

Immunotherapy of mice with an irradiated melanoma vaccine coupled with interleukin-12.用辐照黑素瘤疫苗联合白细胞介素-12对小鼠进行免疫治疗。

Clin Exp Metastasis. 1999 Feb;17(1):63-70. doi: 10.1023/a:1026434323112.

Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study.用白细胞介素-7基因修饰的自体黑色素瘤细胞进行疫苗接种可增强临床状态良好的患者外周血中的抗黑色素瘤溶解活性：一项I期临床研究。

Br J Cancer. 1998 Jun;77(11):1907-16. doi: 10.1038/bjc.1998.317.

本文引用的文献

Determination of granulocyte/macrophage-colony-stimulating factor secretion by human melanoma cells and its effects on human melanoma cell proliferation.人黑色素瘤细胞粒细胞/巨噬细胞集落刺激因子分泌的测定及其对人黑色素瘤细胞增殖的影响。

J Cancer Res Clin Oncol. 1993;119(8):501-3. doi: 10.1007/BF01215933.

Genes coding for tumor rejection antigens: perspectives for specific immunotherapy.编码肿瘤排斥抗原的基因：特异性免疫疗法的前景

Important Adv Oncol. 1994:53-69.

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.用经基因工程改造以分泌小鼠粒细胞巨噬细胞集落刺激因子的辐照肿瘤细胞进行疫苗接种，可刺激产生强大、特异且持久的抗肿瘤免疫力。

Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3539-43. doi: 10.1073/pnas.90.8.3539.

Lysis of allogeneic and autologous melanoma cells by IL-7-induced lymphokine-activated killer cells.白细胞介素-7诱导的淋巴因子激活杀伤细胞对同种异体和自体黑色素瘤细胞的溶解作用。

Br J Cancer. 1994 Jul;70(1):54-9. doi: 10.1038/bjc.1994.249.

Interleukin-7 induces differential lymphokine-activated killer cell activity against human melanoma cells, keratinocytes, and endothelial cells.

J Invest Dermatol. 1994 Jun;102(6):838-42. doi: 10.1111/1523-1747.ep12382320.

Retroviral interleukin 4 gene transfer into an interleukin 4-dependent cell line results in autocrine growth but not in tumorigenicity.逆转录病毒白细胞介素4基因转导入依赖白细胞介素4的细胞系可导致自分泌生长，但不会导致致瘤性。

Eur J Immunol. 1990 Apr;20(4):935-8. doi: 10.1002/eji.1830200433.

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.将白细胞介素2基因导入肿瘤细胞可消除致瘤性并诱导保护性免疫。

J Exp Med. 1990 Oct 1;172(4):1217-24. doi: 10.1084/jem.172.4.1217.

Therapy for cutaneous melanoma: an update.皮肤黑色素瘤的治疗：最新进展

J Am Acad Dermatol. 1990 Feb;22(2 Pt 1):159-76. doi: 10.1016/0190-9622(90)70019-e.

Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity.逆转录病毒载体介导的γ-干扰素基因转移至肿瘤细胞可产生强大且持久的抗肿瘤免疫力。

Cancer Res. 1990 Dec 15;50(24):7820-5.

Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.肿瘤细胞靶向性肿瘤坏死因子α基因转移后的肿瘤抑制作用

J Exp Med. 1991 May 1;173(5):1047-52. doi: 10.1084/jem.173.5.1047.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验