形成离子通道的大肠杆菌素

Ion channel forming colicins.

作者信息

Stroud R

机构信息

Department of Biochemistry and Biophysics, UCSF School of Medicine 94143-0448, USA.

出版信息

Curr Opin Struct Biol. 1995 Aug;5(4):514-20. doi: 10.1016/0959-440x(95)80037-9.

DOI:10.1016/0959-440x(95)80037-9

PMID:8528768

Abstract

Entry of proteins into membranes and transmembrane ion channel formation are two fundamental aspects of membrane biology. The ion channel forming colicins beautifully exemplify both properties. Recent results delineate the structure of a whole colicin; coupled with new biophysical studies, a mechanism for insertion is proposed.

摘要

蛋白质进入膜以及跨膜离子通道的形成是膜生物学的两个基本方面。形成离子通道的大肠杆菌素完美地体现了这两种特性。最近的研究结果描绘了完整大肠杆菌素的结构；结合新的生物物理研究，提出了一种插入机制。