Arakawa K, Miura S, Koga M, Kinoshita A, Urata H, Kiyonaga A
Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.
Hypertens Res. 1995 Jun;18 Suppl 1:S73-7. doi: 10.1291/hypres.18.supplementi_s73.
Physical exercise is one of the life-style modifications used for lowering blood pressure. Except for diminished norepinephrine spill over, the mechanism by which physical exercise exerts its effects was not known. Based on our preliminary finding that the reduction of blood pressure was inversely correlated to the baseline plasma renin activity, we have consequently revealed that mild exercise reduces plasma volume and hence the cardiac index. In order to elucidate the mechanism, we have investigated all possible parameters relevant to plasma volume regulation. Among them, urinary free dopamine and urinary active kallikrein increased in the early stages (weeks 2-4) while atrio-natriuretic factor (week 4) and endogeneous ouabain-like substance (EOLS) consequently (weeks 7-10) decreased. Serum taurine increased and plasma norepinephrine decreased in the late stages. The conclusion reached is that mild exercise seems to first activate the renal dopamine and kallikrein systems and second trigger other mechanism, such as an increase in taurine and decreases in EOLS and norepinephrine.
体育锻炼是用于降低血压的生活方式改变之一。除了去甲肾上腺素溢出减少外，体育锻炼发挥其作用的机制尚不清楚。基于我们的初步发现，即血压降低与基线血浆肾素活性呈负相关，我们因此揭示了轻度运动可减少血浆量，从而降低心脏指数。为了阐明其机制，我们研究了与血浆量调节相关的所有可能参数。其中，尿游离多巴胺和尿活性激肽释放酶在早期阶段（第2 - 4周）增加，而心房利钠因子（第4周）和内源性哇巴因样物质（EOLS）随后（第7 - 10周）减少。血清牛磺酸在后期增加，血浆去甲肾上腺素减少。得出的结论是，轻度运动似乎首先激活肾多巴胺和激肽释放酶系统，其次触发其他机制，如牛磺酸增加、EOLS和去甲肾上腺素减少。
