A role for T cells in the pathogenesis of treatment-resistant Lyme arthritis.
作者信息
Kamradt T, Krause A, Burmester G R
机构信息
Medizinische Universitätsklinik und Poliklinik III, Rheumatologie und Klinische Immunologie, Charité, Berlin, Germany.
出版信息
Mol Med. 1995 Jul;1(5):486-90.
Abstract
摘要
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HLA type and immune response to Borrelia burgdorferi outer surface protein a in people in whom arthritis developed after Lyme disease vaccination.莱姆病疫苗接种后发生关节炎的人群中 HLA 类型及对伯氏疏螺旋体外膜蛋白 a 的免疫反应
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Modulation of cytokine release in ex vivo-stimulated blood from borreliosis patients.莱姆病患者体外刺激血液中细胞因子释放的调节
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Lipopeptides of Borrelia burgdorferi outer surface proteins induce Th1 phenotype development in alphabeta T-cell receptor transgenic mice.伯氏疏螺旋体外膜蛋白的脂肽可诱导αβT细胞受体转基因小鼠的Th1表型发育。
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Dominant recognition of a Borrelia burgdorferi outer surface protein A peptide by T helper cells in patients with treatment-resistant Lyme arthritis.治疗抵抗性莱姆关节炎患者的T辅助细胞对伯氏疏螺旋体外膜蛋白A肽的显性识别
Infect Immun. 1996 Apr;64(4):1284-9. doi: 10.1128/iai.64.4.1284-1289.1996.
本文引用的文献
1
The biological and social phenomenon of Lyme disease.莱姆病的生物学和社会现象。
Science. 1993 Jun 11;260(5114):1610-6. doi: 10.1126/science.8503006.
2
Lyme disease.莱姆病
Rheum Dis Clin North Am. 1993 May;19(2):399-426.
3
Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues.对严重的伯氏疏螺旋体诱导性关节炎的遗传性易感性是显性的，并且与大量螺旋体在组织中的持续存在有关。
Infect Immun. 1994 Feb;62(2):492-500. doi: 10.1128/iai.62.2.492-500.1994.
4
Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis.采用聚合酶链反应检测莱姆关节炎患者滑液中的伯氏疏螺旋体DNA。
N Engl J Med. 1994 Jan 27;330(4):229-34. doi: 10.1056/NEJM199401273300401.
5
Persistence of Borrelia burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis.伯氏疏螺旋体在一名慢性莱姆病患者韧带组织中的持续存在。
Arthritis Rheum. 1993 Nov;36(11):1621-6. doi: 10.1002/art.1780361118.
6
Safety and immunogenicity of a recombinant outer surface protein A Lyme vaccine.重组外表面蛋白A莱姆病疫苗的安全性和免疫原性。
JAMA. 1994 Jun 8;271(22):1764-8.
7
Balance of synovial fluid IL-1 beta and IL-1 receptor antagonist and recovery from Lyme arthritis.滑液白细胞介素-1β与白细胞介素-1受体拮抗剂的平衡及莱姆关节炎的恢复
Lancet. 1993 Jan 16;341(8838):146-8. doi: 10.1016/0140-6736(93)90006-3.
8
The persistence of spirochetal nucleic acids in active Lyme arthritis.活性莱姆关节炎中螺旋体核酸的持续存在。
Ann Intern Med. 1994 Mar 15;120(6):487-9. doi: 10.7326/0003-4819-120-6-199403150-00007.
9
Protection against Borrelia burgdorferi infection in SCID mice is conferred by presensitized spleen cells and partially by B but not T cells alone.致敏脾细胞可使严重联合免疫缺陷（SCID）小鼠获得抗伯氏疏螺旋体感染的能力，且部分是由B细胞介导，而非单独由T细胞介导。
Int Immunol. 1994 May;6(5):671-81. doi: 10.1093/intimm/6.5.671.
10
Lyme disease: an infectious and postinfectious syndrome.莱姆病：一种感染性和感染后综合征。
J Rheumatol. 1994 Mar;21(3):454-61.
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