Wolfe B M, Nisker J A, Hutton L C, Rutt B K
Department of Medicine, University Hospital, London, Ontario.
Clin Invest Med. 1995 Oct;18(5):362-9.
It is not known whether female hormonal replacement therapy (HRT) influences fasting plasma lipoprotein lipids in diet-treated hypercholesterolemic subjects. Thirteen moderately hypercholesterolemic postmenopausal women were studied during dietary treatment alone with a low fat, low cholesterol diet for the 3 months and during the subsequent 2 y of HRT with dl-norgestrel (0.075 mg daily) and estradiol-17 beta (1 mg, 25 of 28 days) with maintenance of the same diet. Hormonal replacement therapy decreased plasma total cholesterol by 11 +/- 3% (5.7 vs. 6.4 mmol/L, p < 0.005), due to a 17 +/- 3% mean reduction (p < 0.001) in the concentration of plasma low density lipoprotein cholesterol (3.9 vs. 4.7 mmol/L, p < 0.001). The ratio of plasma total cholesterol to high density lipoprotein cholesterol fell significantly by 17 +/- 4% (4.1 vs. 4.9, p < 0.005). Mean fasting plasma concentrations of total triglycerides (1.1 vs. 1.6 mmol/L, p < 0.005) fell by 31 +/- 6%, and very low density lipoprotein triglycerides (0.56 vs. 0.83 mmol/L, p < 0.02) by 33 +/- 9%. Hormonal replacement therapy was well-tolerated, improved mood levels, and increased the mineral content of the vertebral spine significantly, while effectively relieving vasomotor flushing. Hormonal replacement therapy complements the dietary treatment of hypercholesterolemia.
目前尚不清楚女性激素替代疗法（HRT）是否会影响饮食治疗的高胆固醇血症患者的空腹血浆脂蛋白脂质。对13名中度高胆固醇血症的绝经后女性进行了研究，她们在3个月内仅采用低脂、低胆固醇饮食进行饮食治疗，随后在接下来的2年接受HRT，服用炔诺酮（每日0.075毫克）和17β-雌二醇（1毫克，28天中的25天），同时维持相同饮食。激素替代疗法使血浆总胆固醇降低了11±3%（5.7对6.4毫摩尔/升，p<0.005），这是由于血浆低密度脂蛋白胆固醇浓度平均降低了17±3%（p<0.001）（3.9对4.7毫摩尔/升，p<0.001）。血浆总胆固醇与高密度脂蛋白胆固醇的比值显著下降了17±4%（4.1对4.9，p<0.005）。空腹血浆总甘油三酯的平均浓度（1.1对1.6毫摩尔/升，p<0.005）下降了31±6%，极低密度脂蛋白甘油三酯（0.56对0.83毫摩尔/升，p<0.02）下降了33±9%。激素替代疗法耐受性良好，改善了情绪水平，显著增加了脊柱的矿物质含量，同时有效缓解了血管舒缩性潮红。激素替代疗法补充了高胆固醇血症的饮食治疗。
