Benekli M, Savaş M C, Güllü I H, Kadayifçi A, Akpek G, Kars A, Güler N, Kansu E, Tekuzman G, Firat D
Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Chemotherapy. 1995 Nov-Dec;41(6):470-2. doi: 10.1159/000239384.
We report here a 16-year-old boy with pre-B-type acute lymphoblastic leukemia who developed acute tumor lysis syndrome (TLS) following 12 h mitoxantrone infusion. TLS is a distinct clinical entity which has been recognized most frequently with aggressive combination chemotherapy of rapidly proliferating hematologic neoplasms. There have been a few reports of single-agent-induced tumor lysis, but to our knowledge, this is the first case reported with mitoxantrone alone.