磺脲类药物的胰腺外效应。
Extrapancreatic effects of sulfonylurea drugs.
作者信息
Kaku K, Inoue Y, Kaneko T
机构信息
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Japan.
出版信息
Diabetes Res Clin Pract. 1995 Aug;28 Suppl:S105-8. doi: 10.1016/0168-8227(95)01078-r.
PMID:8529502
Abstract
Extrapancreatic action of sulfonylurea (SU) drugs were extensively summarized. Hypoglycemic SU drugs stimulate glycolytic pathway and inhibit gluconeogenic pathway in the liver through regulating key enzymes such as the bifunctional enzyme PFK2/F-2,6-P2ase and PEPCK. It is possible that SUs improve the primary defects in NIDDM through both pancreatic and extrapancreatic actions.
摘要
磺脲类（SU）药物的胰腺外作用已被广泛总结。降糖SU药物通过调节关键酶，如双功能酶PFK2/F-2,6-P2酶和磷酸烯醇式丙酮酸羧激酶（PEPCK），刺激肝脏中的糖酵解途径并抑制糖异生途径。磺脲类药物可能通过胰腺和胰腺外作用改善非胰岛素依赖型糖尿病（NIDDM）的主要缺陷。
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