Erdogru T, Agaçfidan A, Onel M, Badur S, Ang O, Telalloglu S
Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Turkey.
J Int Med Res. 1995 Sep-Oct;23(5):386-93. doi: 10.1177/030006059502300510.
In an uncontrolled study, the efficacy of azithromycin in the treatment of non-gonococcal urethritis was assessed in 41 male patients aged between 20 and 40 years with a mean age of 27 +/- 5 years. Clinical and microbiological diagnosis confirmed that 28 men were found positive for Chlamydia trachomatis, 10 for Ureaplasma urealyticum and three for both C. trachomatis and U. urealyticum. All patients received 1 g azithromycin orally (four 250 mg capsules). The length of time between the treatment and following visits were 7-10 days and 14-21 days for second and third visits, respectively. Complete eradication was achieved in 27 out of 41 patients. Of the remaining 14, six were found positive for C. trachomatis and were excluded as they did not return for the follow-up visit, one patient did not achieve complete eradication, one patient infected with both C. trachomatis and U. urealyticum failed to achieve complete eradication, and six patients infected with U. urealyticum failed to be completely cured. No adverse effects were reported in any patient. Single dose administration of 1 g azithromycin appears to be an effective and well-tolerated treatment for chlamydial urethritis and an advantage in terms of patient compliance.
在一项非对照研究中，对41名年龄在20至40岁之间、平均年龄为27±5岁的男性患者评估了阿奇霉素治疗非淋菌性尿道炎的疗效。临床和微生物学诊断证实，28名男性沙眼衣原体检测呈阳性，10名解脲脲原体检测呈阳性，3名沙眼衣原体和解脲脲原体均呈阳性。所有患者口服1克阿奇霉素（四粒250毫克胶囊）。第二次和第三次随访的治疗与随访间隔时间分别为7至10天和14至21天。41名患者中有27名实现了完全根除。其余14名患者中，6名沙眼衣原体检测呈阳性，因未返回进行随访而被排除，1名患者未实现完全根除，1名同时感染沙眼衣原体和解脲脲原体的患者未实现完全根除，6名感染解脲脲原体的患者未完全治愈。没有任何患者报告有不良反应。单剂量服用1克阿奇霉素似乎是治疗衣原体尿道炎的一种有效且耐受性良好的方法，在患者依从性方面具有优势。
