棒状链霉菌中克拉维酸的生物合成：基因克隆与特性分析。
Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization.
作者信息
Hodgson J E, Fosberry A P, Rawlinson N S, Ross H N, Neal R J, Arnell J C, Earl A J, Lawlor E J
机构信息
SmithKline Beecham Pharmaceuticals, Betchworth, Surrey, UK.
出版信息
Gene. 1995 Dec 1;166(1):49-55. doi: 10.1016/0378-1119(95)00560-9.
PMID:8529893
Abstract
Seven classes of Streptomyces clavuligerus mutants defective in clavulanic acid (CLA) biosynthesis have been identified and used to clone the chromosomal DNA encoding eight CLA biosynthetic genes. The complete sequences of three and the partial sequences of two of these biosynthetic genes are reported, together with their known or predicted functions.
摘要
已鉴定出七类在棒酸（CLA）生物合成方面存在缺陷的棒状链霉菌突变体，并利用它们克隆了编码八个CLA生物合成基因的染色体DNA。报道了其中三个生物合成基因的完整序列和两个生物合成基因的部分序列，以及它们已知或预测的功能。
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