Steingrímsson E, Sawadogo M, Gilbert D J, Zervos A S, Brent R, Blanar M A, Fisher D E, Copeland N G, Jenkins N A
Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Maryland 21702, USA.
Genomics. 1995 Jul 20;28(2):179-83. doi: 10.1006/geno.1995.1129.
The genes for the bHLH-Zip transcription factors Tfap4, Mxi1, Tcfeb, Usf1, and Usf2 have been mapped in mouse by interspecific backcross analysis. Mxi1, Usf1, and Usf2 have been mapped previously by in situ hybridization, but their positions on the meiotic linkage map had not been determined. The other two genes have not previously been mapped in mouse. These transcription factors belong to a growing family of transcriptional regulators, some of which are known to form a complex network of interacting proteins that control cell proliferation and apoptosis. As expected, based on mapping studies of other bHLH-Zip genes, these loci were well distributed among mouse chromosomes. In addition, some of the probes used in this study detected multiple, independently segregating loci, suggesting the possible existence of additional family members or species-specific pseudogenes.
通过种间回交分析，已在小鼠中定位了bHLH-Zip转录因子Tfap4、Mxi1、Tcfeb、Usf1和Usf2的基因。Mxi1、Usf1和Usf2先前已通过原位杂交进行了定位，但它们在减数分裂连锁图谱上的位置尚未确定。另外两个基因此前未在小鼠中进行定位。这些转录因子属于一个不断扩大的转录调节因子家族，其中一些已知会形成控制细胞增殖和凋亡的相互作用蛋白的复杂网络。正如基于其他bHLH-Zip基因的定位研究所预期的那样，这些基因座在小鼠染色体中分布良好。此外，本研究中使用的一些探针检测到多个独立分离的基因座，这表明可能存在其他家族成员或物种特异性假基因。
